Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.
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Prevention of DNA re-replication in eukaryotic cellsReplication licensing and cancer--a fatal entanglement?Mechanisms to control rereplication and implications for cancer.Ring of Change: CDC48/p97 Drives Protein Dynamics at ChromatinQuaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityReplication fork instability and the consequences of fork collisions from rereplicationChromosomal Replication Complexity: A Novel DNA Metrics and Genome Instability FactorCDC6: from DNA replication to cell cycle checkpoints and oncogenesisThe APC/C inhibitor, Emi1, is essential for prevention of rereplicationThe Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.Checkpoint effects and telomere amplification during DNA re-replication in fission yeast.Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope.Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis.Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases.Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplicationKDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumorsSingle-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination.Replication licensing and the DNA damage checkpoint.Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.Genomic Instability Induced By Human Papillomavirus Oncogenes.Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damageThe p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 functionCdc6 expression represses E-cadherin transcription and activates adjacent replication origins.Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATRRegulation of DNA replication during development.The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human isletsTargeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agentsRe-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.Human papillomavirus E7 induces rereplication in response to DNA damageSequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.Regression supports two mechanisms of fork processing in phage T4.Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
P2860
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P2860
Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Deregulated replication licens ...... h head-to-tail fork collision.
@en
type
label
Deregulated replication licens ...... h head-to-tail fork collision.
@en
prefLabel
Deregulated replication licens ...... h head-to-tail fork collision.
@en
P2860
P1433
P1476
Deregulated replication licens ...... th head-to-tail fork collision
@en
P2093
Anatoliy Li
Iain F Davidson
P2860
P304
P356
10.1016/J.MOLCEL.2006.09.010
P50
P577
2006-11-01T00:00:00Z