Optimization of antitumor modulators of pre-mRNA splicing.
about
Modulating splicing with small molecular inhibitors of the spliceosomeThe splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.The spliceosome is a therapeutic vulnerability in MYC-driven cancer.Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Small Molecule Modulators of Pre-mRNA Splicing in Cancer TherapyInterchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stagesMutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia.Therapeutic targeting of splicing in cancer.Splicing factor gene mutations in hematologic malignancies.Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.A Challenging Pie to Splice: Drugging the Spliceosome.PRPF8 is important for BRCA1-mediated homologous recombination.Alternative Splicing as a Target for Cancer Treatment.A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma.Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency
P2860
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P2860
Optimization of antitumor modulators of pre-mRNA splicing.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Optimization of antitumor modulators of pre-mRNA splicing.
@en
type
label
Optimization of antitumor modulators of pre-mRNA splicing.
@en
prefLabel
Optimization of antitumor modulators of pre-mRNA splicing.
@en
P2093
P2860
P356
P1476
Optimization of antitumor modulators of pre-mRNA splicing
@en
P2093
Burgess Freeman
Chandraiah Lagisetti
Gustavo Palacios
Thomas R Webb
Tinopiwa Goronga
P2860
P304
10033-10044
P356
10.1021/JM401370H
P407
P577
2013-12-11T00:00:00Z