CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds
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Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substratesInhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activityDifferences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolitesExplaining the atypical reaction profiles of heme enzymes with a novel mechanistic hypothesis and kinetic treatmentGlucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sitesStructural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations.Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in RatsCYP2E1 metabolism of styrene involves allostery.Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates.Sex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver.Structure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes.Effect of BI-1 on insulin resistance through regulation of CYP2E1.CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.Cooperative properties of cytochromes P450.Cooperative effects for CYP2E1 differ between styrene and its metabolites.Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsZebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like.Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures.Spectroscopic studies of the cytochrome P450 reaction mechanisms.New QSAR Models for Human Cytochromes P450, 1A2, 2D6 and 3A4 Implicated in the Metabolism of Drugs. Relevance of Dataset on Model Development.Inhibition of aromatase activity in MCF-7aro human breast cancer cells by the natural androgens testosterone and androstenedione.Cytochrome P450 structure-function: insights from molecular dynamics simulations.Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitorsπ-π Stacking mediated drug-drug interactions in human CYP2E1.Toxicological Implications of Mitochondrial Localization of CYP2E1.Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses.
P2860
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P2860
CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
CYP2E1 substrate inhibition. M ...... site for monocyclic compounds
@en
type
label
CYP2E1 substrate inhibition. M ...... site for monocyclic compounds
@en
prefLabel
CYP2E1 substrate inhibition. M ...... site for monocyclic compounds
@en
P2093
P2860
P356
P1476
CYP2E1 substrate inhibition. M ...... site for monocyclic compounds
@en
P2093
Amber M Burch
Martin D Perry
Ryan M Laddusaw
Samuel L Collom
P2860
P304
P356
10.1074/JBC.M707630200
P407
P577
2007-12-04T00:00:00Z