Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
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Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanismp62/SQSTM1 functions as a signaling hub and an autophagy adaptorProteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregatesRNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stressp62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradationActivation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells.Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons.Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationCytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's DiseaseIncreased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.Neuronal aggregates: formation, clearance, and spreading.Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes.Emerging roles of autophagy in metabolism and metabolic disorders.HX-1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression.Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease.The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila.The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells.HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasisImpaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor.SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity.p62 filaments capture and present ubiquitinated cargos for autophagy.The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses.Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2DThe N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology
P2860
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P2860
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
@en
type
label
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
@en
prefLabel
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
@en
P2093
P2860
P356
P1476
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
@en
P2093
Keiji Tanaka
Lynn Bedford
Masayuki Yamamoto
Myung-Shik Lee
R John Mayer
Ryosuke Ishimura
Satoshi Kametaka
Satoshi Waguri
Shun Kageyama
Takefumi Uemura
P2860
P304
24944-24955
P356
10.1074/JBC.M114.580357
P407
P577
2014-07-21T00:00:00Z