Evolution of CCR5 use before and during coreceptor switching
about
Genetic architecture of HIV-1 genes circulating in north India & their functional implicationsUnderstanding the HIV coreceptor switch from a dynamical perspective.Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein regionConstrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry.Adoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques.Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infectionsCo-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India.The role of genetic variants of Stromal cell-Derived Factor 1 in pediatric HIV-1 infection and disease progression.Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C.Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapyEfficiency of CCR5 coreceptor utilization by the HIV quasispecies increases over time, but is not associated with disease progression.CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity.Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.Identification of interdependent variables that influence coreceptor switch in R5 SHIV(SF162P3N)-infected macaques.Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clonesDevelopment of a novel codon-specific polymerase chain reaction for the detection of CXCR4-utilizing HIV type 1 subtype B.How HIV changes its tropism: evolution and adaptation?Coreceptors and HIV-1 pathogenesis.Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins.Critical amino acids within the human immunodeficiency virus type 1 envelope glycoprotein V4 N- and C-terminals contribute to virus entry.Virus-Host Gene Interactions Define HIV-1 Disease Progression.High-Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia.Sensitivity changes over the course of infection increases the likelihood of resistance against fusion but not CCR5 receptor blockers.Discordance in HIV-1 co-receptor use prediction by different genotypic algorithms and phenotype assay: intermediate profile in relation to concordant predictions.
P2860
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P2860
Evolution of CCR5 use before and during coreceptor switching
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Evolution of CCR5 use before and during coreceptor switching
@en
type
label
Evolution of CCR5 use before and during coreceptor switching
@en
prefLabel
Evolution of CCR5 use before and during coreceptor switching
@en
P2093
P2860
P356
P1433
P1476
Evolution of CCR5 use before and during coreceptor switching
@en
P2093
Donald E Mosier
James I Mullins
Janelle Salkowitz
Laura Heath
Mia Coetzer
Rebecca Nedellec
Sherry McLaughlin
P2860
P304
11758-11766
P356
10.1128/JVI.01141-08
P407
P577
2008-09-24T00:00:00Z