A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
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Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeAdvances in kinase inhibition: treating rheumatic diseases and beyond.Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.Selective JAK inhibitors in development for rheumatoid arthritis.Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation.Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.Therapeutic potential of tyrosine kinase 2 in autoimmunity.Toward selective TYK2 inhibitors as therapeutic agents for the treatment of inflammatory diseases.Selective JAK inhibitors.Safety, tolerability, efficacy and pharmacodynamics of the selective JAK1 inhibitor GSK2586184 in patients with systemic lupus erythematosus.Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.JAK inhibition in inflammatory bowel disease.SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells.Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.IL-23 signaling in Th17 cells is inhibited by HIV infection and is not restored by HAART: Implications for persistent immune activation.TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.Expression of Janus Kinase 1 in vitiligo & psoriasis before and after narrow band UVB: a case-control study.Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.
P2860
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P2860
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
A restricted role for TYK2 cat ...... vel TYK2-selective inhibitors.
@en
type
label
A restricted role for TYK2 cat ...... vel TYK2-selective inhibitors.
@en
prefLabel
A restricted role for TYK2 cat ...... vel TYK2-selective inhibitors.
@en
P2093
P2860
P356
P1476
A restricted role for TYK2 cat ...... vel TYK2-selective inhibitors.
@en
P2093
Adam R Johnson
Anne Van Abbema
Birong Zhang
Calum Macleod
Christine Chang
Christopher A Hurley
Hart S Dengler
Hidenobu Kanda
Janice Smith
P2860
P304
P356
10.4049/JIMMUNOL.1202859
P407
P577
2013-07-26T00:00:00Z