Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.
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Cancer as a metabolic diseaseHuman AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target ProteinRepair of oxidative DNA damage and cancer: recent progress in DNA base excision repairEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleBase Excision Repair, a Pathway Regulated by Posttranslational ModificationsNucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsUbiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5.Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosisRescue of enzymatic function for disease-associated RPE65 proteins containing various missense mutations in non-active sites.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsNucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair.Posttranslational modification of mammalian AP endonuclease (APE1).Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expressionScreening E3 substrates using a live phage display libraryKnock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionUbiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stabilityRequirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylationOxidative genome damage and its repair: implications in aging and neurodegenerative diseases.S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neuronsDifferential expression of hepatic apurinic/apyrimidinic endonuclease 1, a DNA repair enzyme, in chronic hepatitis.Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.Human apurinic/apyrimidinic endonuclease 1.Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.Functions of disordered regions in mammalian early base excision repair proteins.Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis.MDM2's social network.Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.Cell death and deubiquitinases: perspectives in cancer.A review on protein-protein interaction network of APE1/Ref-1 and its associated biological functions.BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.
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Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Ubiquitination of mammalian AP ...... he p53-MDM2 signaling pathway.
@en
Ubiquitination of mammalian AP endonuclease
@nl
type
label
Ubiquitination of mammalian AP ...... he p53-MDM2 signaling pathway.
@en
Ubiquitination of mammalian AP endonuclease
@nl
prefLabel
Ubiquitination of mammalian AP ...... he p53-MDM2 signaling pathway.
@en
Ubiquitination of mammalian AP endonuclease
@nl
P2093
P2860
P356
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P1476
Ubiquitination of mammalian AP ...... he p53-MDM2 signaling pathway.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2009.5
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P577
2009-02-16T00:00:00Z
P5875
P6179
1004972089