Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. - Wikidata - wikimedia - TriplyDB

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

http://www.wikidata.org/entity/Q42013911

about

Using Drosophila to discover mechanisms underlying type 2 diabetes Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells Clinical imaging in regenerative medicine A scalable system for production of functional pancreatic progenitors from human embryonic stem cells Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression Generation of functional human pancreatic β cells in vitro D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells.Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells Neuropeptide Y expression marks partially differentiated β cells in mice and humans Raptor regulates functional maturation of murine beta cells.Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion The transcription factor Myt3 acts as a pro-survival factor in β-cells Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination.In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors.Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.Postnatal β-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1.An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb.Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function Rfx6 maintains the functional identity of adult pancreatic β cells.Postnatal Pancreas of Mice Contains Tripotent Progenitors Capable of Giving Rise to Duct, Acinar, and Endocrine Cells In Vitro.DNA methylation directs functional maturation of pancreatic β cells.Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.Minireview: Directed Differentiation and Encapsulation of Islet β-Cells-Recent Advances and Future Considerations.MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.Nogo-A downregulation improves insulin secretion in mice.Dicer1 is required to repress neuronal fate during endocrine cell maturation.ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

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Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

http://www.wikidata.org/entity/Q42013911

description

2012 nî lūn-bûn

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Functional beta-cell maturatio ...... by expression of urocortin 3.

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Functional beta-cell maturatio ...... by expression of urocortin 3.

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Functional beta-cell maturatio ...... by expression of urocortin 3.

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Functional beta-cell maturatio ...... by expression of urocortin 3.

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Nature Biotechnology

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Functional beta-cell maturatio ...... d by expression of urocortin 3

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Alireza Rezania

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Barak Blum

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Claire Bonal

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Douglas A Melton

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P2860

Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development.

Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis

Pancreatic beta cells require NeuroD to achieve and maintain functional maturity

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell

MafA and MafB regulate genes critical to beta-cells in a unique temporal manner

Pancreas organogenesis: from bud to plexus to gland.

Production of functional glucagon-secreting α-cells from human embryonic stem cells.

Exocytosis of insulin: in vivo maturation of mouse endocrine pancreas.

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3

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