A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.
about
Spatio-temporal simulation of first pass drug perfusion in the liverA mechanistic, model-based approach to safety assessment in clinical developmentIntegrating cellular metabolism into a multiscale whole-body modelRepresentative Sinusoids for Hepatic Four-Scale Pharmacokinetics SimulationsBayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant PopulationsMultiscale computational models of complex biological systems.Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells.From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling.Clinical translation in the virtual liver networkModeling biology spanning different scales: an open challenge.Pharmacodynamic modelling of biomarker data in oncology.Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development.Simulation environment and graphical visualization environment: a COPD use-case.Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance.A detailed physiologically based model to simulate the pharmacokinetics and hormonal pharmacodynamics of enalapril on the circulating endocrine Renin-Angiotensin-aldosterone systemTranslation of Genotype to Phenotype by a Hierarchy of Cell SubsystemsAn update on computational oral absorption simulation.A conceptual review on systems biology in health and diseases: from biological networks to modern therapeutics.Changing face of vaccination in immunocompromised hosts.Physiologically based pharmacokinetic and pharmacodynamic modeling in cancer drug development: status, potential and gaps.Physiologically Based Simulations of Deuterated Glucose for Quantifying Cell Turnover in Humans.Quantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models.Pediatric Development of Bosentan Facilitated by Modeling and Simulation.Sport science integration: An evolutionary synthesis.Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim®.How Informative Are Drug-Drug Interactions of Gene-Drug Interactions?Two different approaches for pharmacokinetic modeling of exhaled drug concentrations.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models.Development of a physiologically based computational kidney model to describe the renal excretion of hydrophilic agents in ratsAnalysis and algorithmic generation of hepatic vascular systemsFirst dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development.A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System.Analysis and simulation of division- and label-structured population models : a new tool to analyze proliferation assays.Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine.A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.Reduced order modeling and analysis of the human complement system.Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.
P2860
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P2860
A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A computational systems biolog ...... d molecular reaction networks.
@en
A computational systems biolog ...... d molecular reaction networks.
@nl
type
label
A computational systems biolog ...... d molecular reaction networks.
@en
A computational systems biolog ...... d molecular reaction networks.
@nl
prefLabel
A computational systems biolog ...... d molecular reaction networks.
@en
A computational systems biolog ...... d molecular reaction networks.
@nl
P2093
P2860
P356
P1476
A computational systems biolog ...... nd molecular reaction networks
@en
P2093
Bernd Ludewig
Christoph Niederalt
Corina Becker
Hans-Ulrich Siegmund
Juergen Jaeger
Juri Solodenko
Katrin Coboeken
Kirstin Thelen
Linus Goerlitz
Michael Block
P2860
P356
10.3389/FPHYS.2011.00004
P577
2011-02-24T00:00:00Z