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Spatio-temporal simulation of first pass drug perfusion in the liverA mechanistic, model-based approach to safety assessment in clinical developmentEvaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulationIntegrating cellular metabolism into a multiscale whole-body modelRepresentative Sinusoids for Hepatic Four-Scale Pharmacokinetics SimulationsBayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant PopulationsModel-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.Metabolic functions of duplicate genes in Saccharomyces cerevisiae.Efficient classification of complete parameter regions based on semidefinite programming.Ensemble modeling for analysis of cell signaling dynamics.Enabling multiscale modeling in systems medicine.Clinical translation in the virtual liver networkUsing expression data for quantification of active processes in physiologically based pharmacokinetic modeling.A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.Metabolic flux distributions: genetic information, computational predictions, and experimental validation.Modeling and Simulation of In Vivo Drug Effects.Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy.Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases.Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.Towards whole-body systems physiology.A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.The virtual liver: state of the art and future perspectives.Stoichiometric modelling of microbial metabolism.Zonated quantification of steatosis in an entire mouse liver.
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Lars Kuepfer
@ast
Lars Kuepfer
@en
Lars Kuepfer
@es
Lars Kuepfer
@nl
Lars Kuepfer
@sl
type
label
Lars Kuepfer
@ast
Lars Kuepfer
@en
Lars Kuepfer
@es
Lars Kuepfer
@nl
Lars Kuepfer
@sl
prefLabel
Lars Kuepfer
@ast
Lars Kuepfer
@en
Lars Kuepfer
@es
Lars Kuepfer
@nl
Lars Kuepfer
@sl
P106
P1153
56095324700
P21
P31
P496
0000-0002-8741-7786