Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition. - Wikidata - wikimedia - TriplyDB

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

http://www.wikidata.org/entity/Q42039544

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An MCASE approach to the search of a cure for Parkinson's Disease.Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.Radiochemistry devoted to the production of monoamine oxidase (MAO-A and MAO-B) ligands for brain imaging with positron emission tomography.Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond.Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease.The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells.Protective effect of N-(2-propynyl)-2-(5-benzyloxyindolyl) methylamine (PF 9601N), a novel MAO-B inhibitor, on dopamine-lesioned PC12 cultured cells.Predicting targets of compounds against neurological diseases using cheminformatic methodology.Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.N-(furan-2-ylmethyl)-N-methylprop-2-yn-1-amine (F2MPA): A potential cognitive enhancer with MAO inhibitor properties.

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P2860

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

http://www.wikidata.org/entity/Q42039544

description

1999 nî lūn-bûn

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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1999年论文

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1999年论文

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name

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

@en

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

@nl

type

label

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

@en

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

@nl

prefLabel

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

@en

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

@nl

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British Journal of Pharmacology

P1476

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition.

@en

P2093

E Fernández-Alvarez

http://www.w3.org/2001/XMLSchema#string

J L Marco

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M Unzeta

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V Pérez

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P2860

cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties

The effect of deprenyl (selegiline) on the natural history of Parkinson's disease

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

Interactions of monoamine oxidase with substrates and inhibitors.

Selective inhibitors of monoamine oxidase (MAO-A and MAO-B) as probes of its catalytic site and mechanism.

The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline.

Monoamine oxidase inhibitory potencies and selectivities of 2-[N-(2-propynyl)-aminomethyl]-1-methyl indole derivatives.

Probing the active sites of monoamine oxidase A and B with 1,4-disubstituted tetrahydropyridine substrates and inactivators.

5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.

Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors.

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869-876

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scholarly article

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10.1038/SJ.BJP.0702600

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4

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127

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1999-06-01T00:00:00Z

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227877049

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10433493

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1566084

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