Tryprostatin A, a specific and novel inhibitor of microtubule assembly
about
Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance proteinNordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.Biochemical characterization of a novel indole prenyltransferase from Streptomyces sp. SN-593(1'S)-4-(3,4-Dichlorophenyl)-1'-(3,5-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2-spiro-2'-pyrrolizidine-3'-spiro-3''-indoline-1,2''-dione.Ethyl 3'-cyano-1'-methyl-2-oxo-4'-phenylspiro-[acenaphthene-1,2'-pyrrolidine]-3'-carboxyl-ate.Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of fumigaclavine C synthase FGAPT1.Protein-protein interactions: mechanisms and modification by drugs.Peptides with anticancer use or potential.Disruption of protein-protein interactions: towards new targets for chemotherapy.Engineered Production of Tryprostatins in E. coli through Reconstitution of a Partial ftm Biosynthetic Gene Cluster from Aspergillus spIndole, a core nucleus for potent inhibitors of tubulin polymerization.Actin- and microtubule-targeting bioprobes: their binding sites and inhibitory mechanisms.Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases.Applications of dimethylallyltryptophan synthases and other indole prenyltransferases for structural modification of natural products.Revisiting ligand-induced conformational changes in proteins: essence, advancements, implications and future challenges.Developments around the bioactive diketopiperazines: a patent review.Fungal metabolites with anticancer activity.Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies.A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer.Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A.Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin.Quick and simple detection technique to assess the binding of antimicrotubule agents to the colchicine-binding site.6'-Amino-3'-methyl-2-oxo-1'-phenyl-1',3a',4',7a'-tetra-hydrospiro-[1H-indole-3(2H),4'-pyrano[2,3-d]pyrazole]-5'-carbonitrile.Total synthesis of tryprostatins A and B.Reconstruction of pyrrolo[2,3-b]indoles carrying an alpha-configured reverse C3-dimethylallyl moiety by using recombinant enzymes.Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterisation.A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus-Host Interactions.Three structures of dispirooxindole derivatives generated in situ through a three-component one-pot strategy with complete regio- and stereoselectivity.A regioselective multicomponent protocol for the synthesis of novel bioactive 4-hydroxyquinolin-2(1H)-one grafted monospiropyrrolidine and thiapyrrolizidine hybrids
P2860
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P2860
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
@en
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
@nl
type
label
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
@en
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
@nl
prefLabel
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
@en
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
@nl
P2093
P2860
P356
P1433
P1476
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
@en
P2093
P2860
P304
P356
10.1042/BJ3330543
P407
P478
333 ( Pt 3)
P50
P577
1998-08-01T00:00:00Z