about
The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludinNordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.Amphidinolide h, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament.Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells.Garbled messages and corrupted translations.Regulating microtubule properties by modifying their organizing minus ends.Actin- and microtubule-targeting bioprobes: their binding sites and inhibitory mechanisms.Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line.Vicenistatin induces early endosome-derived vacuole formation in mammalian cells.Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells.Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B.The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle.Irciniastatin A induces potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung carcinoma A549 cells.Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation.Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1.Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation.Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane.The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin.Chemical modification of reveromycin A and its biological activities.Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin.Tryprostatin A, a specific and novel inhibitor of microtubule assemblyIrciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition.Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A.4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.A K-252a-resistance gene, sks1+, encodes a protein similar to the Caenorhabditis elegans F37 A4.5 gene product and confers multidrug resistance in Schizosaccharomyces pombe.A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate.Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization.Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Takeo Usui
@ast
Takeo Usui
@en
Takeo Usui
@es
Takeo Usui
@nl
Takeo Usui
@sl
type
label
Takeo Usui
@ast
Takeo Usui
@en
Takeo Usui
@es
Takeo Usui
@nl
Takeo Usui
@sl
prefLabel
Takeo Usui
@ast
Takeo Usui
@en
Takeo Usui
@es
Takeo Usui
@nl
Takeo Usui
@sl
P106
P21
P31
P496
0000-0003-2377-7499
P569
2000-01-01T00:00:00Z