Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine. - Wikidata - wikimedia - TriplyDB

Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.

Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.

http://www.wikidata.org/entity/Q42068538

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Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias Hereditary spastic paraplegia SPG4: what is known and not known about the disease.Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila.An automated climbing apparatus to measure chemotherapy-induced neurotoxicity in Drosophila melanogaster.Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP).Drosophila melanogaster in the study of human neurodegeneration.Drosophila melanogaster: a new model to study cisplatin-induced neurotoxicity.BMP signaling and microtubule organization regulate synaptic strength Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations.Spastin binds to lipid droplets and affects lipid metabolism.Katanin regulates dynamics of microtubules and biogenesis of motile cilia.Aging perturbs 26S proteasome assembly in Drosophila melanogaster All neuropathies great and small.The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations The genetics of hereditary spastic paraplegia and implications for drug therapy.Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons.In vivo assay of presynaptic microtubule cytoskeleton dynamics in Drosophila.Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization.Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia.Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.The synaptic cytoskeleton in development and disease.Cellular pathways of hereditary spastic paraplegia.Importance of gene dosage in controlling dendritic arbor formation during development.Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders.Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways.Colonic motor dysfunctions in a mouse model of high-fat diet-induced obesity: an involvement of A2B adenosine receptors.Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation.Patient-Derived Stem Cell Models in HSP: Disease Modelling and Drug Discovery Functional differences of short and long isoforms of spastin harboring missense mutation Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives

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Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.

http://www.wikidata.org/entity/Q42068538

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2005 nî lūn-bûn

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Disease-related phenotypes in ...... by treatment with vinblastine.

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Elena Sartori

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Genny Orso

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Maria Giovanna Rossetto

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Mel Feany

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P2860

Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

Life extension in Drosophila by feeding a drug.

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)

Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia

Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia

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3026-3034

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Andrea Martinuzzi

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