DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes - Wikidata - wikimedia - TriplyDB

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

http://www.wikidata.org/entity/Q42117977

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Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage.Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout.CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383.Osteoarthritis: a disease of the joint as an organ.Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation Epigenetic regulation during fetal femur development: DNA methylation matters.The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis.SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes.Characterization of the cartilage DNA methylome in knee and hip osteoarthritis Genome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity Epigenetics and Osteoarthritis.Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis Articular cartilage degradation in osteoarthritis.Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation.Epigenetic mechanisms underlying the aberrant catabolic and anabolic activities of osteoarthritic chondrocytes.miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectively Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis.Identification of differentially methylated regions in new genes associated with knee osteoarthritis.Epigenetics and the transition from acute to chronic pain.Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis.Epigenetically mediated spontaneous reduction of NFAT1 expression causes imbalanced metabolic activities of articular chondrocytes in aged mice.Epigenetic and microRNA regulation during osteoarthritis development Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis.Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.Human chondrocyte cultures as models of cartilage-specific gene regulation.Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, α-Ketoglutarate (α-KG), and DNA hydroxymethylation levels by interleukin-1β in primary human chondrocytes.Cellular senescence in osteoarthritis pathology.Epigenetic modifications of interleukin-6 in synovial fibroblasts from osteoarthritis patients The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine.Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine.Epigenetics in osteoarthritis and its implication for future therapeutics.Epigenetic mechanisms and non-coding RNAs in osteoarthritis.Epigenetics of osteoarticular diseases: recent developments.

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P2860

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

http://www.wikidata.org/entity/Q42117977

description

2009 nî lūn-bûn

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name

DNA demethylation at specific ...... n human articular chondrocytes

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DNA demethylation at specific ...... n human articular chondrocytes

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type

label

DNA demethylation at specific ...... n human articular chondrocytes

@en

DNA demethylation at specific ...... n human articular chondrocytes

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prefLabel

DNA demethylation at specific ...... n human articular chondrocytes

@en

DNA demethylation at specific ...... n human articular chondrocytes

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Arthritis & Rheumatology

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DNA demethylation at specific ...... n human articular chondrocytes

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Helmtrud I Roach

http://www.w3.org/2001/XMLSchema#string

Ko Hashimoto

http://www.w3.org/2001/XMLSchema#string

Marc B Gibson

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Mary B Goldring

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Richard O C Oreffo

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P2860

DNA methylation patterns and epigenetic memory

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression

Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes

The complex language of chromatin regulation during transcription

Phenotypic plasticity and the epigenetics of human disease

Stability and flexibility of epigenetic gene regulation in mammalian development

Multiple signals converging on NF-kappaB.

DNA methylation and the regulation of gene transcription.

The role of cytokines in cartilage matrix degeneration in osteoarthritis.

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3303-3313

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10.1002/ART.24882

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11

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60

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