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The nuclear lamina is mechano-responsive to ECM elasticity in mature tissueTherapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New TricksStem cell mechanobiology: diverse lessons from bone marrowContractile forces sustain and polarize hematopoiesis from stem and progenitor cells.Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin.Nuclear lamins in cancer"Marker of Self" CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumorsLabel-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells.Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival.Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates.Physical plasticity of the nucleus and its manipulation.Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiationHeart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating.Photoinitiated destruction of composite porphyrin-protein polymersomesFractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor.Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis.Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes.Interior decoration: Adapting multiwell plates for high throughput mechanobiology.Photo-responsive hydrogels with photoswitchable mechanical properties allow time-resolved analysis of cellular responses to matrix stiffening.Design of functional ferritin-like proteins with hydrophobic cavities.Efficient self-assembly of Archaeoglobus fulgidus ferritin around metallic cores.An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness.Structure and activity of apoferritin-stabilized gold nanoparticlesSubcellular organization: change of phase in partitioning the cellular milieuNuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loadingMechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretionMicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasisCircadian control of the secretory pathway maintains collagen homeostasisLaser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Joe Swift
@ast
Joe Swift
@en
Joe Swift
@es
Joe Swift
@nl
Joe Swift
@sl
type
label
Joe Swift
@ast
Joe Swift
@en
Joe Swift
@es
Joe Swift
@nl
Joe Swift
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prefLabel
Joe Swift
@ast
Joe Swift
@en
Joe Swift
@es
Joe Swift
@nl
Joe Swift
@sl
P106
P1153
13607483700
P21
P31
P496
0000-0002-5039-9094