Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.
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Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosomeTwo interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug designTrypanosoma Cruzi-Induced Host Immune System Dysfunction: A Rationale for Parasite Immunosuppressive Factor(s) Encoding Gene TargetingFormation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania.Drug resistance analysis by next generation sequencing in LeishmaniaThe narrow active-site cleft of O-acetylserine sulfhydrylase from Leishmania donovani allows complex formation with serine acetyltransferases with a range of C-terminal sequencesInhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallographyCharacterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from TrypanosomaTrypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressDual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovaniMultiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencingMolecular mechanisms of drug resistance in natural Leishmania populations vary with genetic backgroundDevelopment of novel prime-boost strategies based on a tri-gene fusion recombinant L. tarentolae vaccine against experimental murine visceral leishmaniasisCathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulationLive vaccination tactics: possible approaches for controlling visceral leishmaniasisFormation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nucleaseMetabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical diseaseSystems analysis of metabolism in the pathogenic trypanosomatid Leishmania majorBis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxificationTemperature increase prevails over acidification in gene expression modulation of amastigote differentiation in Leishmania infantum.Genetically modified organisms and visceral leishmaniasisDiametrically opposed effects of hypoxia and oxidative stress on two viral transactivatorsEvidence that free GPI glycolipids are essential for growth of Leishmania mexicana.The parasite-specific trypanothione metabolism of trypanosoma and leishmania.Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus.Identification of a disulfide isomerase protein of Leishmania major as a putative virulence factor.A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.The switch region on Leishmania major chromosome 1 is not required for mitotic stability or gene expression, but appears to be essential.Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages.The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesisA plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis.Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining MechanismDown-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survivalInhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.
P2860
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P2860
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Disruption of the trypanothion ...... idative stress in macrophages.
@en
Disruption of the trypanothion ...... idative stress in macrophages.
@nl
type
label
Disruption of the trypanothion ...... idative stress in macrophages.
@en
Disruption of the trypanothion ...... idative stress in macrophages.
@nl
prefLabel
Disruption of the trypanothion ...... idative stress in macrophages.
@en
Disruption of the trypanothion ...... idative stress in macrophages.
@nl
P2093
P2860
P356
P1433
P1476
Disruption of the trypanothion ...... xidative stress in macrophages
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/16.10.2590
P407
P577
1997-05-01T00:00:00Z