A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
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Generation of β cells from human pluripotent stem cells: are we there yet?Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cellsConcise review: A chemical approach to control cell fate and functionDerivation of insulin-producing beta-cells from human pluripotent stem cellsStem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?Dickkopf Wnt signaling pathway inhibitor 1 regulates the differentiation of mouse embryonic stem cells in vitro and in vivoWIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signalingBulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cellsStem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injuryRapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markersEndoderm complexity in the mouse gastrula is revealed through the expression of spink3.Wnt signaling and the control of human stem cell fate.Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell.MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.Potential for pancreatic maturation of differentiating human embryonic stem cells is sensitive to the specific pathway of definitive endoderm commitment.Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.The Importance of the Canonical Wnt Signaling Pathway in the Porcine Endometrial Stromal Stem/Progenitor Cells: Implications for RegenerationConvergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.Signaling networks in human pluripotent stem cells.The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.Efficient derivation of lateral plate and paraxial mesoderm subtypes from human embryonic stem cells through GSKi-mediated differentiation.Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition.GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes.Ontogenesis of hepatic and pancreatic stem cells.Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation.Potential for pharmacological manipulation of human embryonic stem cells.Stem cell-based tissue engineering approaches for musculoskeletal regeneration.Pluripotent stem cells as a potential tool for disease modelling and cell therapy in diabetes.Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway.Stem Cells in Skeletal Tissue Engineering: Technologies and Models.Wnt/β-Catenin and MEK-ERK Signaling are Required for Fibroblast-Derived Extracellular Matrix-Mediated Endoderm Differentiation of Embryonic Stem Cells.WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCsMicroRNA target sites as genetic tools to enhance promoter-reporter specificity for the purification of pancreatic progenitor cells from differentiated embryonic stem cells.Capturing Human Naïve Pluripotency in the Embryo and in the Dish.StemCellCKB: An Integrated Stem Cell-Specific Chemogenomics KnowledgeBase for Target Identification and Systems-Pharmacology Research.
P2860
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P2860
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A novel chemically directed ro ...... based on inhibition of GSK-3.
@en
A novel chemically directed ro ...... based on inhibition of GSK-3.
@en-gb
A novel chemically directed ro ...... based on inhibition of GSK-3.
@nl
type
label
A novel chemically directed ro ...... based on inhibition of GSK-3.
@en
A novel chemically directed ro ...... based on inhibition of GSK-3.
@en-gb
A novel chemically directed ro ...... based on inhibition of GSK-3.
@nl
prefLabel
A novel chemically directed ro ...... based on inhibition of GSK-3.
@en
A novel chemically directed ro ...... based on inhibition of GSK-3.
@en-gb
A novel chemically directed ro ...... based on inhibition of GSK-3.
@nl
P2093
P2860
P356
P1476
A novel chemically directed ro ...... s based on inhibition of GSK-3
@en
P2093
Christopher E Goldring
Heather K Bone
Melanie J Welham
P2860
P304
P356
10.1242/JCS.081679
P407
P577
2011-05-24T00:00:00Z