Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. - Wikidata - wikimedia - TriplyDB

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.

http://www.wikidata.org/entity/Q42126323

about

Analytics for Metabolic Engineering GNAT-like strategy for polyketide chain initiation Conformational switch triggered by -ketoglutarate in a halogenase of curacin A biosynthesis Vinylogous chain branching catalysed by a dedicated polyketide synthase module Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module A mechanism-based aryl carrier protein/thiolation domain affinity probe.Adenylation enzyme characterization using gamma -(18)O(4)-ATP pyrophosphate exchange.Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690.Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange Metamorphic enzyme assembly in polyketide diversification.Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo.Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase Practical 4'-phosphopantetheine active site discovery from proteomic samples.Proteomic analysis of polyketide and nonribosomal peptide biosynthesis Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms.Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.Polyketide proofreading by an acyltransferase-like enzyme.A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth.Accessing natural product biosynthetic processes by mass spectrometry.Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange.A proteomics approach to discovering natural products and their biosynthetic pathways.Polyketide stereocontrol: a study in chemical biology.Fungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis.The structural role of the carrier protein--active controller or passive carrier.Insights into the chemical logic and enzymatic machinery of NRPS assembly lines.Biosynthesis of polyketides by trans-AT polyketide synthases.Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects.Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1.Deconstruction of iterative multidomain polyketide synthase function.Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A.Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase.Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis.

P2860

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P2860

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.

http://www.wikidata.org/entity/Q42126323

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Facile detection of acyl and p ...... ring tandem mass spectrometry.

@en

Facile detection of acyl and p ...... ring tandem mass spectrometry.

@nl

type

label

Facile detection of acyl and p ...... ring tandem mass spectrometry.

@en

Facile detection of acyl and p ...... ring tandem mass spectrometry.

@nl

prefLabel

Facile detection of acyl and p ...... ring tandem mass spectrometry.

@en

Facile detection of acyl and p ...... ring tandem mass spectrometry.

@nl

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Facile detection of acyl and p ...... ring tandem mass spectrometry.

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P2093

Christopher T Calderone

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Christopher T Walsh

http://www.w3.org/2001/XMLSchema#string

Neil L Kelleher

http://www.w3.org/2001/XMLSchema#string

Pieter C Dorrestein

http://www.w3.org/2001/XMLSchema#string

Roberto Kolter

http://www.w3.org/2001/XMLSchema#string

Stefanie B Bumpus

http://www.w3.org/2001/XMLSchema#string

P2860

Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue

Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry.

Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster.

A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection.

Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42.

Selective identification and differentiation of N- and O-linked oligosaccharides in glycoproteins by liquid chromatography-mass spectrometry.

Polyketide and nonribosomal peptide antibiotics: modularity and versatility.

Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5.

Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.

Mobile and localized protons: a framework for understanding peptide dissociation.

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12756-12766

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10.1021/BI061169D

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42

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45

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Sylvie Garneau-Tsodikova

Zachary D. Aron

Paul D. Straight

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2006-10-01T00:00:00Z

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6754075

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17042494

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2518290

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