Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.
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Aflatoxin and deconstruction of type I, iterative polyketide synthase functionPolyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthasesDemonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksAIn Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic.Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase functionInvestigation of fungal iterative polyketide synthase functions using partially assembled intermediates.Rational reprogramming of fungal polyketide first-ring cyclizationThioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons.Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases.The structures of type I polyketide synthases.Assembly line polyketide synthases: mechanistic insights and unsolved problems.Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.Navigating the fungal polyketide chemical space: from genes to molecules.Analysis of the Sequences, Structures, and Functions of Product-Releasing Enzyme Domains in Fungal Polyketide Synthases.Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis.Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products.Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8Assembly line termination in cylindrocyclophane biosynthesis: discovery of an editing type II thioesterase domain in a type I polyketide synthase.In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis.The International Conference of Natural Product Biosynthesis (ICNPB, 8th US-Japan seminar on the Biosynthesis of Natural Products).Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin.
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P2860
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Interrogation of global active ...... taining biosynthetic fidelity.
@ast
Interrogation of global active ...... taining biosynthetic fidelity.
@en
type
label
Interrogation of global active ...... taining biosynthetic fidelity.
@ast
Interrogation of global active ...... taining biosynthetic fidelity.
@en
prefLabel
Interrogation of global active ...... taining biosynthetic fidelity.
@ast
Interrogation of global active ...... taining biosynthetic fidelity.
@en
P2093
P2860
P356
P1476
Interrogation of global active ...... taining biosynthetic fidelity.
@en
P2093
Anna L Vagstad
Craig A Townsend
Katherine Belecki
Neil L Kelleher
Stefanie B Bumpus
P2860
P304
P356
10.1021/JA3016389
P407
P577
2012-04-09T00:00:00Z