Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
about
Perspective on computational and structural aspects of kinase discovery from IPK2014AutoSite: an automated approach for pseudo-ligands prediction-from ligand-binding sites identification to predicting key ligand atoms.MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cellsFragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.MELK is not necessary for the proliferation of basal-like breast cancer cells.CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials.Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
P2860
Q30373565-074C1DDC-DDE8-4638-8DB6-5FB907385760Q30389927-318A0616-DCE9-48C0-B2F0-902153AC2EC7Q36275700-930F0F07-32CE-439E-89F8-CA0E97E1BBAFQ41108643-46C42ED9-02E1-467F-BCE4-426320A0A47CQ41705554-7FE94D4D-A9C5-4799-9FF3-940F8DAE6992Q42108657-FD72348F-69EA-4A55-9188-C13353FCC96AQ42553482-2BD68C39-BE6F-482D-86B8-E14971D5A00D
P2860
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Fragment-based discovery of ty ...... bryonic leucine zipper kinase.
@en
Fragment-based discovery of ty ...... bryonic leucine zipper kinase.
@nl
type
label
Fragment-based discovery of ty ...... bryonic leucine zipper kinase.
@en
Fragment-based discovery of ty ...... bryonic leucine zipper kinase.
@nl
prefLabel
Fragment-based discovery of ty ...... bryonic leucine zipper kinase.
@en
Fragment-based discovery of ty ...... bryonic leucine zipper kinase.
@nl
P2093
P2860
P356
P1476
Fragment-based discovery of ty ...... bryonic leucine zipper kinase.
@en
P2093
Andrew Sharff
Christopher C F Hamlett
David C Rees
Dirk Brehmer
Eddy J E Freyne
François Sommen
Joannes T M Linders
Joseph E Coyle
Lieven Meerpoel
P2860
P356
10.1021/ML5001245
P577
2014-05-23T00:00:00Z