Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans. - Wikidata - wikimedia - TriplyDB

Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans.

Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans.

http://www.wikidata.org/entity/Q42150838

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Mechanisms of change in gene copy number Palindrome-Mediated Translocations in Humans: A New Mechanistic Model for Gross Chromosomal Rearrangements DNA polymerase θ (POLQ), double-strand break repair, and cancer Snaps and mends: DNA breaks and chromosomal translocations Characterizing complex structural variation in germline and somatic genomes Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome GAP-Seq: a method for identification of DNA palindromes.Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm.Large inverted repeats within Xp11.2 are present at the breakpoints of isodicentric X chromosomes in Turner syndrome.Mitochondrial DNA deletions are associated with non-B DNA conformations Paternal origin of the de novo constitutional t(11;22)(q23;q11).Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.Non-B DNA structure-induced genetic instability and evolution.Potential non-B DNA regions in the human genome are associated with higher rates of nucleotide mutation and expression variation.Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells.Size of gene specific inverted repeat--dependent gene deletion In Saccharomyces cerevisiae.Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture.A parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase.On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation.The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements.Searching for non-B DNA-forming motifs using nBMST (non-B DNA motif search tool)The cellular etiology of chromosome translocations.DNA secondary structures: stability and function of G-quadruplex structures.Genomic disorders ten years on.Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells.Competitive superhelical transitions involving cruciform extrusion ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.Challenges in studying genomic structural variant formation mechanisms: the short-read dilemma and beyond.Sequence and structural basis for chromosomal fragility during translocations in cancer.Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.Self-catalyzed site-specific depurination of G residues mediated by cruciform extrusion in closed circular DNA plasmids.Effects of Replication and Transcription on DNA Structure-Related Genetic Instability Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells.Genomic determinants of somatic copy number alterations across human cancers.Drosophila Model for the Analysis of Genesis of LIM-kinase 1-Dependent Williams-Beuren Syndrome Cognitive Phenotypes: INDELs, Transposable Elements of the Tc1/Mariner Superfamily and MicroRNAs.Spatial control of the GEN1 Holliday junction resolvase ensures genome stability.G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia.Suite of tools for statistical N-gram language modeling for pattern mining in whole genome sequences.

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Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans.

http://www.wikidata.org/entity/Q42150838

description

2008 nî lūn-bûn

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Chromosomal instability mediat ...... rrent translocation in humans.

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Chromosomal instability mediat ...... rrent translocation in humans.

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Chromosomal instability mediat ...... rrent translocation in humans.

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Chromosomal instability mediat ...... rrent translocation in humans.

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Chromosomal instability mediat ...... urrent translocation in humans

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Beverly S Emanuel

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Hasbaira Bolor

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Hidehito Inagaki

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Hiroki Kurahashi

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Mariko Taniguchi

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Takema Kato

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Tamae Ohye

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Tamim H Shaikh

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P2860

Roles of transition nuclear proteins in spermiogenesis

Efficient selection for high-expression transfectants with a novel eukaryotic vector

A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies

Cruciform DNA structure underlies the etiology for palindrome-mediated human chromosomal translocations

Age has no effect on de novo constitutional t(11;22) translocation frequency in sperm.

A palindrome-mediated mechanism distinguishes translocations involving LCR-B of chromosome 22q11.2.

Superhelical torsion in cellular DNA responds directly to environmental and genetic factors.

The constitutional t(17;22): another translocation mediated by palindromic AT-rich repeats.

Mutations in POL1 increase the mitotic instability of tandem inverted repeats in Saccharomyces cerevisiae

AT-rich palindromes mediate the constitutional t(11;22) translocation.

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10.1101/GR.079244.108

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2

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18997000

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2652202

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