Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.
about
Subversion of the actin cytoskeleton during viral infectionHow HIV takes advantage of the cytoskeleton in entry and replicationThe identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancementEpstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.Trans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans.HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss.Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.HIV-1 Nef: at the crossroadsDeterminants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivoDeployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic developmentMechanisms of HIV-1 Nef function and intracellular signaling.The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis.The activity of Nef on HIV-1 infectivityNef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens.HIV-1 Nef and T-cell activation: a history of contradictions.Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.Modulation of HIV pathogenesis and T-cell signaling by HIV-1 NefLentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Involvement of the Rac1-IRSp53-Wave2-Arp2/3 Signaling Pathway in HIV-1 Gag Particle Release in CD4 T Cells.Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins.HIV-1 Nef disrupts membrane-microdomain-associated anterograde transport for plasma membrane delivery of selected Src family kinases.All-Round Manipulation of the Actin Cytoskeleton by HIV.
P2860
Q24633026-818B4E39-01C4-4CFB-B252-F5C71CE098C9Q27021639-B38F5F9A-C593-4628-99CC-034EC3DB1B8BQ28477983-FA25F8C1-61BE-4BE7-949D-848F014EDE6EQ34270437-7B953116-74BF-4F0F-A4B8-57E810BCB8EBQ34403732-3B44D6B6-D5D2-4F77-AB94-5E83B65B6D6EQ35839673-FBECA203-816C-4A48-8106-B0E84A79DB86Q35848314-88316D72-1B91-4CE9-A218-C3C00A61D7B2Q36143620-6687F755-F251-41F4-A1E5-2258EE4F243AQ36926697-F2C75D65-9C19-4239-A6D6-CACE3361E7D4Q37072999-28B937DB-95E7-4310-9398-AB0FD0C34C99Q37127522-B156E17D-8A4F-46E3-A71F-0B167BB41465Q37183848-F57304A9-A9C7-44B7-95C4-FCBF60C2A024Q37415400-C9311EB4-FD2E-4C25-A755-731C72761A38Q37532593-1112FBFC-0086-45C2-99B4-62CACF862B3FQ37595684-D87A06A6-3851-4AF4-AFC8-7E0C6AB0DDEBQ38218107-E1D79902-10BA-4622-B3CA-D4E9A182C63CQ38356666-0E41AE8A-53AA-4F1A-9255-50BB812BEB83Q38951336-310DE0D9-788A-470C-9DC4-B8725E7F3FDBQ39254514-521C42FE-4CDC-4A62-9A7A-373EB2EE6C67Q39321661-3CD6B881-F3A9-4310-B8B3-D53ACAFCA61CQ39358737-ED41031B-380D-4007-B1CA-CB39FA194EDFQ39577894-FAA470F6-6BF3-44AA-995E-BBC7755F3FC5Q39741159-98C8CB47-E485-40AC-A6B6-AA3D9B03B983Q41712949-48ADC59C-7BAC-497F-8387-430C7EBD41A1Q41888042-D35A92C3-674E-426E-9819-EEF1F018D214Q42265942-546F67CA-A035-4B88-AABA-7B909A17FFD0Q48104489-858EBDB4-1CE3-41E9-898E-CE4D6A0834AA
P2860
Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Human immunodeficiency virus t ...... 1-activated kinase 2 activity.
@en
Human immunodeficiency virus t ...... 1-activated kinase 2 activity.
@nl
type
label
Human immunodeficiency virus t ...... 1-activated kinase 2 activity.
@en
Human immunodeficiency virus t ...... 1-activated kinase 2 activity.
@nl
prefLabel
Human immunodeficiency virus t ...... 1-activated kinase 2 activity.
@en
Human immunodeficiency virus t ...... 1-activated kinase 2 activity.
@nl
P2860
P356
P1433
P1476
Human immunodeficiency virus t ...... 1-activated kinase 2 activity.
@en
P2093
Kati Pulkkinen
Susanne Rauch
P2860
P304
P356
10.1128/JVI.02185-07
P407
P577
2007-12-19T00:00:00Z