Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers - Wikidata - wikimedia - TriplyDB

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

http://www.wikidata.org/entity/Q42161299

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TDP-43: a new player on the AD field?Transient dynamics of Aβ contribute to toxicity in Alzheimer's disease Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain.Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.Alzheimer disease: a tale of two prions Techniques for Monitoring Protein Misfolding and Aggregation in Vitro and in Living Cells Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.PrP(Sc)-specific antibodies with the ability to immunodetect prion oligomers.Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques A generic method for design of oligomer-specific antibodies.Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology Amyloid properties of the mouse egg zona pellucida Structure-based design of conformation- and sequence-specific antibodies against amyloid β.A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.Specific soluble oligomers of amyloid-β peptide undergo replication and form non-fibrillar aggregates in interfacial environments Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity.The domestic cat as a natural animal model of Alzheimer's disease.Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases.Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers.Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial What amyloid ligands can tell us about molecular polymorphism and disease.Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence.Dendritic spine density, morphology, and fibrillar actin content surrounding amyloid-β plaques in a mouse model of amyloid-β deposition.Structures of oligomers of a peptide from β-amyloid.Refinement of a DNA based Alzheimer's disease epitope vaccine in rabbits.Context dependence of protein misfolding and structural strains in neurodegenerative diseases.Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer Polymorphism of oligomers of a peptide from β-amyloid.Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory.The role of amyloidogenic protein oligomerization in neurodegenerative disease.Proteotoxicity and cardiac dysfunction.Structural, morphological, and functional diversity of amyloid oligomers.An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations.Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer's Disease Immunotherapy.Potential mechanisms and implications for the formation of tau oligomeric strains.

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Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

http://www.wikidata.org/entity/Q42161299

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2010年論文

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2010年论文

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Conformation dependent monoclo ...... s of prefibrillar Aβ oligomers

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Conformation dependent monoclo ...... s of prefibrillar Aβ oligomers

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Conformation dependent monoclo ...... s of prefibrillar Aβ oligomers

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Molecular Neurodegeneration

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Anna Pensalfini

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Isabel Canto

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Suhail Rasool

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P2860

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure

Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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