Structure-based design of conformation- and sequence-specific antibodies against amyloid β.
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Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityMechanisms of protein-folding diseases at a glanceMolecular basis of -amyloid oligomer recognition with a conformational antibody fragmentCrystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomersAdvances in Antibody DesignIntrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity.Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.The Surprising Role of Amyloid Fibrils in HIV InfectionTransthyretin-derived peptides as β-amyloid inhibitors.Curli biogenesis: order out of disorder.Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones.The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.A generic method for design of oligomer-specific antibodies.Functional Characteristics and Molecular Mechanism of a New scFv Antibody Against Aβ42 Oligomers and Immature Protofibrils.Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity.Pre-amyloid oligomers of the proteotoxic RepA-WH1 prionoid assemble at the bacterial nucleoidCo-evolution of affinity and stability of grafted amyloid-motif domain antibodies.Engineered Autonomous Human Variable DomainsRational design of potent domain antibody inhibitors of amyloid fibril assembly.Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid PolypeptideEfficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability.Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer's disease.Methods of probing the interactions between small molecules and disordered proteins.Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer's Disease Immunotherapy.Recombinant Antibody Fragments for Neurodegenerative Diseases.AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences.Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans.Peptide binding landscapes: Specificity and homophilicity across sequence space in a lattice model.Turmeric effect on subcutaneous insulin-induced amyloid mass: an in vivo study.Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs.Layers of structure and function in protein aggregation.Oxidized Carbon Black: Preparation, Characterization and Application in Antibody Delivery across Cell Membrane.Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues.Engineering of a peptide probe for β-amyloid aggregates.Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.Conformation-dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencing.Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species.Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
P2860
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P2860
Structure-based design of conformation- and sequence-specific antibodies against amyloid β.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Structure-based design of conf ...... antibodies against amyloid β.
@ast
Structure-based design of conf ...... antibodies against amyloid β.
@en
type
label
Structure-based design of conf ...... antibodies against amyloid β.
@ast
Structure-based design of conf ...... antibodies against amyloid β.
@en
prefLabel
Structure-based design of conf ...... antibodies against amyloid β.
@ast
Structure-based design of conf ...... antibodies against amyloid β.
@en
P2093
P2860
P356
P1476
Structure-based design of conf ...... c antibodies against amyloid β
@en
P2093
Ali Reza A Ladiwala
Joseph M Perchiacca
Moumita Bhattacharya
P2860
P356
10.1073/PNAS.1111232108
P407
P577
2011-12-14T00:00:00Z