Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff. - Wikidata - wikimedia - TriplyDB

Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff.

Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff.

http://www.wikidata.org/entity/Q42172413

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The role of innate versus adaptive immune responses in a mouse model of O'nyong-nyong virus infection Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2 Insect antiviral innate immunity: pathways, effectors, and connections Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses Modulation of type I IFN induction by a virulence determinant within the alphavirus nsP1 protein Interferon Gamma: Influence on Neural Stem Cell Function in Neurodegenerative and Neuroinflammatory Disease Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses.Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels.Chikungunya virus arthritis in adult wild-type mice.A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence.Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells.Identification and characterization of a ross river virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon De novo assembly and transcriptome analysis of Atlantic salmon macrophage/dendritic-like TO cells following type I IFN treatment and Salmonid alphavirus subtype-3 infection.MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma.Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate.Infected dendritic cells are sufficient to mediate the adjuvant activity generated by Venezuelan equine encephalitis virus replicon particles An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid.Treatment with cationic liposome-DNA complexes (CLDCs) protects mice from lethal Western equine encephalitis virus (WEEV) challenge.Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice.Giving CD4+ T cells the slip: viral interference with MHC class II-restricted antigen processing and presentation.Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses.Mechanism of action of mRNA-based vaccines.Sindbis virus induced phosphorylation of IRF3 in human embryonic kidney cells is not dependent on mTOR.Alpha interferon and not gamma interferon inhibits salmonid alphavirus subtype 3 replication in vitro Venezuelan Equine Encephalitis Virus Capsid-The Clever Caper.A determinant of Sindbis virus neurovirulence enables efficient disruption of Jak/STAT signaling.Early events in alphavirus replication determine the outcome of infection.The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling.Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein.Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design.The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent.Patent highlights: December 2015-January 2016.The Methyltransferase-Like Domain of Chikungunya Virus nsP2 Inhibits the Interferon Response by Promoting the Nuclear Export of STAT1 Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs The Pathogenesis of Alphaviruses

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P2860

Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff.

http://www.wikidata.org/entity/Q42172413

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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Venezuelan equine encephalitis ...... s independent of host shutoff.

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Venezuelan equine encephalitis ...... s independent of host shutoff.

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Venezuelan equine encephalitis ...... s independent of host shutoff.

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Venezuelan equine encephalitis ...... s independent of host shutoff.

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Venezuelan equine encephalitis ...... s independent of host shutoff.

@en

Venezuelan equine encephalitis ...... s independent of host shutoff.

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Journal of Virology

P1476

Venezuelan equine encephalitis ...... ms independent of host shutoff

@en

P2093

Alan C Whitmore

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Laura J White

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Robert E Johnston

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Stephanie A Montgomery

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Thomas E Morrison

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P2860

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor

Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations

Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling

Genetic and phenotypic changes accompanying the emergence of epizootic subtype IC Venezuelan equine encephalitis viruses from an enzootic subtype ID progenitor

Resistance to alpha/beta interferons correlates with the epizootic and virulence potential of Venezuelan equine encephalitis viruses and is determined by the 5' noncoding region and glycoproteins

Pegylated alpha interferon is an effective treatment for virulent venezuelan equine encephalitis virus and has profound effects on the host immune response to infection

Inhibition of Transcription and Translation in Sindbis Virus-Infected Cells

Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus.

Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation

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10571-10581

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scholarly article

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10.1128/JVI.01041-09

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20

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83

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Jason D Simmons

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2009-08-05T00:00:00Z

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19656875

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2753124

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