Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation
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Time in Redox Adaptation Processes: From Evolution to HormesisThe role of sirtuins in cellular homeostasisSlowing ageing by design: the rise of NAD(+) and sirtuin-activating compoundsComparative Functional Genomic Analysis of Two Vibrio Phages Reveals Complex Metabolic Interactions with the Host CellA continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins.It takes two to tango: NAD+ and sirtuins in aging/longevity controlUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.Sirtuin-dependent clock control: new advances in metabolism, aging and cancerInvestigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADHSpatial dynamics of SIRT1 and the subnuclear distribution of NADH species.Emerging roles for SIRT5 in metabolism and cancer.Three-Component Aminoalkylations Yielding Dihydronaphthoxazine-Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side-Chains.Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure.Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.SIRT6: Novel Mechanisms and Links to Aging and Disease.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.Chemical and structural biology of protein lysine deacetylasesIdentification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.Modulation of Mitochondrial Membrane Potential and ROS Generation by Nicotinamide in a Manner Independent of SIRT1 and MitophagyA Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of the Dabcyl Quencher.SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones.Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.Characterization of CobB kinetics and inhibition by nicotinamide.Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.Molecular system identification for enzyme directed evolution and design.Development of Activity-Based Chemical Probes for Human Sirtuins.LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes.Crystal structures of SIRT3 reveal that the α2-α3 loop and α3-helix affect the interaction with long-chain acyl lysine.New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.Biophysical characterization of hit compounds for mechanism-based enzyme activation.Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2Liver regeneration in aged mice: new insightsSirtuins and Immuno-Metabolism of SepsisReconstitution of Mammalian Enzymatic Deacylation Reactions in Live Bacteria Using Native Acylated Substrates
P2860
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P2860
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD
@nl
Kinetic and Structural Basis f ...... Sirtuin-Catalyzed Deacylation
@en
type
label
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD
@nl
Kinetic and Structural Basis f ...... Sirtuin-Catalyzed Deacylation
@en
prefLabel
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD
@nl
Kinetic and Structural Basis f ...... Sirtuin-Catalyzed Deacylation
@en
P2093
P2860
P50
P1433
P1476
Kinetic and Structural Basis f ...... Sirtuin-Catalyzed Deacylation
@en
P2093
Akihiro Ito
Jessica L Feldman
John M Denu
Julie N Thelen
P2860
P304
P356
10.1021/ACS.BIOCHEM.5B00150
P407
P577
2015-05-04T00:00:00Z