Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite.
about
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitroHuman exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer.Metabolism of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in isolated liver cells from guinea pig, hamster, mouse, and ratNon-covalent DNA groove-binding by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminusHeterocyclic aromatic amines induce DNA strand breaks and cell transformation.DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2,3-b]indole (A(alpha)C) and 2-amino-3-methyl-9H-pyridol2,3-b]indole (MeA(alpha)C) in human and rat hepatic microsomes.Anophthalmia in litters of female rats treated with the food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses.Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
P2860
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P2860
Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Genotoxicity of the food mutag ...... y acting genotoxic metabolite.
@en
Genotoxicity of the food mutag ...... y acting genotoxic metabolite.
@nl
type
label
Genotoxicity of the food mutag ...... y acting genotoxic metabolite.
@en
Genotoxicity of the food mutag ...... y acting genotoxic metabolite.
@nl
prefLabel
Genotoxicity of the food mutag ...... y acting genotoxic metabolite.
@en
Genotoxicity of the food mutag ...... y acting genotoxic metabolite.
@nl
P2093
P356
P1433
P1476
Genotoxicity of the food mutag ...... y acting genotoxic metabolite.
@en
P2093
Alexander J
Brunborg G
Hongslo JK
Søderlund EJ
P304
P356
10.1093/CARCIN/10.8.1389
P407
P577
1989-08-01T00:00:00Z