Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.
about
Choosing an effective protein bioconjugation strategyEnabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineeringRI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cellsHomogeneous bispecifics by disulfide bridging.Bromomaleimide-linked bioconjugates are cleavable in mammalian cellsA HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy.Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.Carbon nanotubes allow capture of krypton, barium and lead for multichannel biological X-ray fluorescence imaging.Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation.Chemical Protein Modification through Cysteine.Towards the next generation of biomedicines by site-selective conjugation.A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome.Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries.Next-generation disulfide stapling: reduction and functional re-bridging all in one.Bromopyridazinedione-mediated protein and peptide bioconjugation.A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.Reducible, dibromomaleimide-linked polymers for gene delivery.Reversible protein affinity-labelling using bromomaleimide-based reagents.Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging.A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis.Redox tunable delivery systems: sweet block copolymer micelles via thiol-(bromo)maleimide conjugation.A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.Dibromomaleimide as a facile, versatile linker for delivery applications.Dibromomaleimide Derivative as an Efficient Polymer Coupling Agent for Building Topological PolymersFluorescent and chemico-fluorescent responsive polymers from dithiomaleimide and dibromomaleimide functional monomersCross-conjugation of DNA, proteins and peptides via a pH switchAryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds
P2860
Q28253030-5632689E-B7D6-4C17-B188-4A5D4D5DF0A3Q33587970-1FC66961-0AEE-4A8D-AE02-F8339157CAA8Q34273832-044C10C7-2F7C-45A9-BC3E-F95948615BCFQ35692638-8C6EB0E3-80CD-4415-BCB1-0F1761E86FB5Q35873697-B89CE29D-5F4B-4065-8D63-D211F6099B6FQ36097775-E4334DB7-6B10-42E3-9C66-C5E69F84712BQ36708427-C56CE550-9DFA-491B-97AA-0C00003B9C5AQ37393169-A83C5182-3A45-4D5A-83E5-62C5D1D9DD90Q38497871-D7955835-16D5-492D-B202-B7A5E4F76044Q38704033-52B9EFE6-C771-422D-86EC-E3D6655C5E4DQ38706553-6324C5F5-47D3-4B57-A7C7-7A481A0DB778Q38892876-17DE326F-4851-47A1-B2D7-A18197B806C0Q38990118-888BADAC-7FD6-4E9A-90A6-5D24E4E8F488Q39851489-8A368837-9319-4958-809C-037406AC525AQ41773582-D0A756F1-A8BF-4214-A2E0-BF4F955927A3Q42041757-FC53A18A-E016-45D6-B904-762BDCB9362DQ42095021-A59FEDAE-746B-4354-8F55-409F206F9E4EQ42176571-FFA43B6D-9C46-4139-8028-BEB73604A2E6Q42585959-DE5DD193-7E0F-4927-AD1B-456DC62BCC23Q42585968-829BF156-4E98-4D7A-954D-7146529A912CQ42699301-15486518-8098-4E3D-B4CD-A3158E17F642Q42871498-1DFB5828-68A3-475A-851F-D2E0560984ACQ43154296-BEF17C5D-5BD7-4662-BF9C-0CA289500F98Q48131836-1E6836A6-EF58-42FC-986D-83A61CD98212Q50227663-D12A9D33-71BF-468A-8946-5F9D8B7867E1Q51033890-568FFD35-3771-48FA-BC76-A11F5CA7ED8BQ51693417-130F5E20-3926-4B55-B342-89F9AFFE3614Q57342993-BE823648-4F4D-47D7-B8A9-275733C0C72FQ57368373-F8E24BE4-3472-4216-AE08-5A7320067FB7Q57729196-5D47C19D-E8B5-474D-83B5-3E081A375308Q58293196-1580D1F1-E184-48FF-92CD-33044ABCDDCD
P2860
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Tunable reagents for multi-fun ...... ntrol of maleimide hydrolysis.
@en
Tunable reagents for multi-fun ...... ntrol of maleimide hydrolysis.
@nl
type
label
Tunable reagents for multi-fun ...... ntrol of maleimide hydrolysis.
@en
Tunable reagents for multi-fun ...... ntrol of maleimide hydrolysis.
@nl
prefLabel
Tunable reagents for multi-fun ...... ntrol of maleimide hydrolysis.
@en
Tunable reagents for multi-fun ...... ntrol of maleimide hydrolysis.
@nl
P2093
P2860
P356
P1476
Tunable reagents for multi-fun ...... ntrol of maleimide hydrolysis.
@en
P2093
Chris P Ryan
Danai Papaioannou
Dina Grohmann
Felix F Schumacher
Finn Werner
Gabriel Waksman
James R Baker
Mark E B Smith
Stephen Caddick
P2860
P304
P356
10.1039/C1CC11114K
P407
P577
2011-04-05T00:00:00Z