Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing
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A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicingSplicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleusHuman homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingInteraction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55kEvidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammalsPrp8 protein: at the heart of the spliceosomeIdentification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle controlAn upstream AG determines whether a downstream AG is selected during catalytic step II of splicingA novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionRegulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicingCrystal structure of the functional domain of the splicing factor Prp18A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae.Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae.Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression.Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.Mutational analysis identifies two separable roles of the Saccharomyces cerevisiae splicing factor Prp18.Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing.Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits.Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B" protein.Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicingFunctional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturationPrp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicingFunctional association of essential splicing factor(s) with PRP19 in a protein complex.Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Central region of the human splicing factor Hprp3p interacts with Hprp4pMutations in U5 snRNA loop 1 influence the splicing of different genes in vivo.Genetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast.The RNA splicing factor hSlu7 is required for correct 3' splice-site choice.Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutationsIdentification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.
P2860
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P2860
Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Synthetic lethal mutations sug ...... or the second step of splicing
@en
Synthetic lethal mutations sug ...... or the second step of splicing
@nl
type
label
Synthetic lethal mutations sug ...... or the second step of splicing
@en
Synthetic lethal mutations sug ...... or the second step of splicing
@nl
prefLabel
Synthetic lethal mutations sug ...... or the second step of splicing
@en
Synthetic lethal mutations sug ...... or the second step of splicing
@nl
P2093
P2860
P356
P1476
Synthetic lethal mutations sug ...... or the second step of splicing
@en
P2093
P2860
P304
P356
10.1128/MCB.12.11.5197
P407
P577
1992-11-01T00:00:00Z