A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.
about
Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptorBeyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Mass spectrometry-based proteomics of human cannabinoid receptor 2: covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation.The essential role for aromatic cluster in the β3 adrenergic receptorIdentification of functionally important residues of the silkmoth pheromone biosynthesis-activating neuropeptide receptor, an insect ortholog of the vertebrate neuromedin U receptor.Mapping substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid.Action of molecular switches in GPCRs--theoretical and experimental studies.Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.The role of Cysteine 6.47 in class A GPCRsA phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors.Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activationStructure-Function Basis of Attenuated Inverse Agonism of Angiotensin II Type 1 Receptor Blockers for Active-State Angiotensin II Type 1 Receptor.Homology modeling and molecular dynamics simulations of the active state of the nociceptin receptor reveal new insights into agonist binding and activation.Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.Molecular Pharmacology of δ-Opioid Receptors.Structure and dynamics of a constitutively active neurotensin receptor.Lipid bilayer modules as determinants of K+ channel gating.Two intracellular helices of G-protein coupling receptors could generally support oligomerization and coupling with transducers.Progress in structure based drug design for G protein-coupled receptors.MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation?G-protein-coupled receptor dynamics: dimerization and activation models compared with experiment.Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods.Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5).Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor.Ligand chain length drives activation of lipid G protein-coupled receptors.Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119.Current topics in angiotensin II type 1 receptor research: Focus on inverse agonism, receptor dimerization and biased agonism.A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.Structure of the first sphingosine 1-phosphate receptor.Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7.Retinal Conformation Changes Rhodopsin's Dynamic Ensemble.Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation.High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs.Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond networkStructural and functional roles of small group-conserved amino acids present on helix-H7 in the β(2)-adrenergic receptorEffect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.
P2860
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P2860
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
A conserved aromatic lock for ...... seven-transmembrane receptors.
@en
A conserved aromatic lock for ...... seven-transmembrane receptors.
@nl
type
label
A conserved aromatic lock for ...... seven-transmembrane receptors.
@en
A conserved aromatic lock for ...... seven-transmembrane receptors.
@nl
prefLabel
A conserved aromatic lock for ...... seven-transmembrane receptors.
@en
A conserved aromatic lock for ...... seven-transmembrane receptors.
@nl
P2093
P2860
P50
P356
P1476
A conserved aromatic lock for ...... seven-transmembrane receptors.
@en
P2093
Louise Valentin-Hansen
Maja S Engelstoft
Pia S Petersen
Rie Nygaard
Thomas M Frimurer
P2860
P304
P356
10.1074/JBC.M109.064725
P407
P577
2009-11-17T00:00:00Z