Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

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Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

P2860

Q48533330-30BF6342-F953-4108-9F82-4D57C47DF206

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Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

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Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

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Item

label

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

@en

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

@nl

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Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

@en

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

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P1476

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

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Akifumi Takaori-Kondo

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Akihiko Yokoyama

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Akinori Kanai

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Hiroshi Okuda

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Hirotaka Matsui

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Satoshi Takahashi

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Takeshi Kawamura

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P2860

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

An RNA polymerase II elongation factor encoded by the human ELL gene

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

hDOT1L links histone methylation to leukemogenesis.

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1918-1931

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scholarly article

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10.1172/JCI91406

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English

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127

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Boban Stanojevic

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2017-04-10T00:00:00Z

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28394257

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5409830

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Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

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P2860

P2860

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932