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A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's diseaseMito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical modelHydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truthEuropean contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism?Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.Real-time measurements of amino acid and protein hydroperoxides using coumarin boronic acid.Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies.Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications.Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death.Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cellsMitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathyAntiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanismRecent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling.Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants."ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentaryReaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implicationsHydropropidine: a novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide.Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer CellsRole of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection.Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes--Limitations, progress, and perspectives.Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.Detection and identification of oxidants formed during •NO/O2•⁻ reaction: a multi-well plate CW-EPR spectroscopy combined with HPLC analyses.Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid.H2O2 generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology.A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide ToxicityMitochondria-targeted metformins: anti-tumour and redox signalling mechanisms.Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine.Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity.1-Methyl-3-nitropyridine: an efficient oxidant of NADH in non-enzymatic and enzyme-mediated processes.On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment.20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation.Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite.Mitochondria-targeted spin traps: synthesis, superoxide spin trapping, and mitochondrial uptake.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jacek Zielonka
@ast
Jacek Zielonka
@en
Jacek Zielonka
@es
Jacek Zielonka
@nl
Jacek Zielonka
@sl
type
label
Jacek Zielonka
@ast
Jacek Zielonka
@en
Jacek Zielonka
@es
Jacek Zielonka
@nl
Jacek Zielonka
@sl
prefLabel
Jacek Zielonka
@ast
Jacek Zielonka
@en
Jacek Zielonka
@es
Jacek Zielonka
@nl
Jacek Zielonka
@sl
P1053
N-9546-2014
P106
P1153
7004214390
P21
P31
P3829
P496
0000-0002-2524-0145