Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.
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More than a Rumor Spreads in Parkinson's DiseaseMesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis.α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patientsSingle cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation.Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes.Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes.Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine.Exosomes in the Pathology of Neurodegenerative Diseases.Potential Modes of Intercellular α-Synuclein Transmission.Parkinson's disease: Microglial/macrophage-induced immunoexcitotoxicity as a central mechanism of neurodegenerationThe spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links.Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Following the fate of endocytosed fibrils.Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology.Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases.Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.Vertebrate food products as a potential source of prion-like α-synuclein.Alpha-synuclein oligomers: a new hope.The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications.Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread.Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.Prying into the Prion Hypothesis for Parkinson's Disease.Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.A Salutary Role of Reactive Oxygen Species in Intercellular Tunnel-Mediated Communication.Meeting report - Cellular dynamics: membrane-cytoskeleton interface.Import and Export of Misfolded α-Synuclein.Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin.Emerging role of contact-mediated cell communication in tissue development and diseasesAdhesion to nanofibers drives cell membrane remodeling through one-dimensional wettingLRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylationRapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experimentModeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec
P2860
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P2860
Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.
@en
Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.
@nl
type
label
Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.
@en
Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.
@nl
prefLabel
Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.
@en
Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.
@nl
P2093
P2860
P356
P1433
P1476
Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.
@en
P2093
Chiara Zurzolo
Fabrice de Chaumont
Frida Loria
Laura Pieri
Luc Bousset
Ronald Melki
Saïda Abounit
P2860
P304
P356
10.15252/EMBJ.201593411
P407
P577
2016-08-22T00:00:00Z