Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes. - Wikidata - wikimedia - TriplyDB

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

http://www.wikidata.org/entity/Q42388077

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More than a Rumor Spreads in Parkinson's Disease Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis.α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation.Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes.Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes.Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine.Exosomes in the Pathology of Neurodegenerative Diseases.Potential Modes of Intercellular α-Synuclein Transmission.Parkinson's disease: Microglial/macrophage-induced immunoexcitotoxicity as a central mechanism of neurodegeneration The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links.Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Following the fate of endocytosed fibrils.Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology.Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases.Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.Vertebrate food products as a potential source of prion-like α-synuclein.Alpha-synuclein oligomers: a new hope.The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications.Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread.Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.Prying into the Prion Hypothesis for Parkinson's Disease.Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.A Salutary Role of Reactive Oxygen Species in Intercellular Tunnel-Mediated Communication.Meeting report - Cellular dynamics: membrane-cytoskeleton interface.Import and Export of Misfolded α-Synuclein.Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin.Emerging role of contact-mediated cell communication in tissue development and diseases Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec

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P2860

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

http://www.wikidata.org/entity/Q42388077

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2016 nî lūn-bûn

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2016年の論文

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2016年论文

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Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.

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Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.

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Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.

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Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.

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Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.

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Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.

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The EMBO Journal

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Tunneling nanotubes spread fib ...... ular trafficking of lysosomes.

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Chiara Zurzolo

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Fabrice de Chaumont

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Frida Loria

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Laura Pieri

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Luc Bousset

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Ronald Melki

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Saïda Abounit

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Seng Zhu

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P2860

Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Properties of native brain α-synuclein

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

Brief reports: Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes

Staging of brain pathology related to sporadic Parkinson's disease

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

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2120-2138

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scholarly article

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10.15252/EMBJ.201593411

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19

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35

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Jean-Christophe Olivo-Marin

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2016-08-22T00:00:00Z

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27550960

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5048354

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