Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis
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Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateM1 and M2 immune activation in Parkinson's Disease: Foe and ally?Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative DiseasesZn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulationActivation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: Oxidant- and Non-Oxidant-Mediated Triggering Mechanismsβ2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pHVCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.Considerations on the role of environmental toxins in idiopathic Parkinson's disease pathophysiologyBrain disposition of α-Synuclein: roles of brain barrier systems and implications for Parkinson's disease.Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.The role of Galectin-3 in α-synuclein-induced microglial activation.NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cellsNLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes.Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 InflammasomeThe Interplay between Alpha-Synuclein Clearance and SpreadingDirect Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells.SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibitionTargeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerationsImpaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.Accumulation of autophagosomes confers cytotoxicity.Targeting α-synuclein: Therapeutic options.Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.How strong is the evidence that Parkinson's disease is a prion disorder?Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells.Inflammasomes link vascular disease with neuroinflammation and brain disorders.Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance.Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease.NLRP3 inflammasome: Its regulation and involvement in atherosclerosis.The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.
P2860
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P2860
Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Alpha-synuclein induces lysoso ...... species following endocytosis
@ast
Alpha-synuclein induces lysoso ...... species following endocytosis
@en
Alpha-synuclein induces lysoso ...... species following endocytosis
@nl
type
label
Alpha-synuclein induces lysoso ...... species following endocytosis
@ast
Alpha-synuclein induces lysoso ...... species following endocytosis
@en
Alpha-synuclein induces lysoso ...... species following endocytosis
@nl
prefLabel
Alpha-synuclein induces lysoso ...... species following endocytosis
@ast
Alpha-synuclein induces lysoso ...... species following endocytosis
@en
Alpha-synuclein induces lysoso ...... species following endocytosis
@nl
P2093
P2860
P3181
P1433
P1476
Alpha-synuclein induces lysoso ...... species following endocytosis
@en
P2093
Andrew M Burrage
Christopher M Wiethoff
Christopher O'Connor
David Freeman
Edward M Campbell
Kathleen McGuire
Rudy Cedillos
Samantha Choyke
Shauna Marvin
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0062143
P407
P577
2013-01-01T00:00:00Z