Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO. - Wikidata - wikimedia - TriplyDB

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

http://www.wikidata.org/entity/Q42412768

about

Splicing therapy for neuromuscular disease Silencing disease genes in the laboratory and the clinic Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice.Novel target for peptide-based imaging and treatment of brain tumors Delivery is key: lessons learnt from developing splice-switching antisense therapies Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy Morpholino-mediated increase in soluble Flt-1 expression results in decreased ocular and tumor neovascularization The status of exon skipping as a therapeutic approach to duchenne muscular dystrophy Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth.Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy.Current status of pharmaceutical and genetic therapeutic approaches to treat DMD.Duchenne muscular dystrophy gene therapy: Lost in translation?Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice.Pre-exercise low-level laser therapy improves performance and levels of oxidative stress markers in mdx mice subjected to muscle fatigue by high-intensity exercise.How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides.Progress in gene therapy of dystrophic heart disease.Novel compounds for the treatment of Duchenne muscular dystrophy: emerging therapeutic agents Prospect of gene therapy for cardiomyopathy in hereditary muscular dystrophy.Development of multiexon skipping antisense oligonucleotide therapy for Duchenne muscular dystrophy Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation.Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice.Eteplirsen in the treatment of Duchenne muscular dystrophy The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy.Targeting RNA to treat neuromuscular disease.Cell-matrix interactions in muscle disease.Cell-penetrating peptides for the delivery of nucleic acids.Update on the treatment of Duchenne muscular dystrophy.Cell penetration: scope and limitations by the application of cell-penetrating peptides.Peptide-based vectors: recent developments.Sequence-defined polymers for the delivery of oligonucleotides.Exon skipping: a first in class strategy for Duchenne muscular dystrophy.Highly efficient in vivo delivery of PMO into regenerating myotubes and rescue in laminin-α2 chain-null congenital muscular dystrophy mice.The Relation Between Thermodynamic and Structural Properties and Cellular Uptake of Peptides Containing Tryptophan and Arginine.Antisense mediated exon skipping therapy for duchenne muscular dystrophy (DMD)

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P2860

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

http://www.wikidata.org/entity/Q42412768

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

@en

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

@nl

type

label

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

@en

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

@nl

prefLabel

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

@en

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

@nl

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Molecular Therapy

P1476

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

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P2093

Corinne Betts

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Haifang Yin

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Hong M Moulton

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Jordan Boutilier

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Matthew Ja Wood

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Qingsong Wang

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Shirin Ashraf

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Thomas Merritt

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P2860

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

Elucidation of muscle-binding peptides by phage display screening.

Octa-guanidine morpholino restores dystrophin expression in cardiac and skeletal muscles and ameliorates pathology in dystrophic mdx mice.

Function and genetics of dystrophin and dystrophin-related proteins in muscle.

Very mild muscular dystrophy associated with the deletion of 46% of dystrophin.

Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse.

Viral vectors for gene transfer to striated muscle.

Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo.

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer.

Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

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1822-1829

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10.1038/MT.2010.151

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10

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45603901

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20700113

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