about
Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteinsSolution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxationProstate-apoptosis response-4 phosphorylation in vascular smooth muscleIntrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin bindingSmooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition.Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins.NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.Assessment of endothelin and copeptin as biomarkers for vasovagal syncope.The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction.Mapping and functional characterization of the murine smoothelin-like 1 promoter.Glycation of wood frog (Rana sylvatica) hemoglobin and blood proteins: in vivo and in vitro studies.The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter.Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.MAPKs represent novel therapeutic targets for gastrointestinal motility disorders.Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure.The regulation of smooth muscle contractility by zipper-interacting protein kinase.C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeatsSmooth muscle phenotypic plasticity in mechanical obstruction of the small intestine.Parasitic helminths: a pharmacopeia of anti-inflammatory molecules.Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease.The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ.Novel contributions of the smoothelin-like 1 protein in vascular smooth muscle contraction and its potential involvement in myogenic tone.Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle.NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations.Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors.Effects of nitric oxide and reactive oxygen species on HIF-1α stabilization following clostridium difficile toxin exposure of the Caco-2 epithelial cell line.Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome.Inhibition of zipper-interacting protein kinase function in smooth muscle by a myosin light chain kinase pseudosubstrate peptide.Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle.A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle.Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase.The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.Cross-talk between Rho-associated kinase and cyclic nucleotide-dependent kinase signaling pathways in the regulation of smooth muscle myosin light chain phosphatase.Vitamin D₃ metabolites enhance the NLRP3-dependent secretion of IL-1β from human THP-1 monocytic cells.The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum.Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase.Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Justin A. MacDonald
@ast
Justin A. MacDonald
@en
Justin A. MacDonald
@es
Justin A. MacDonald
@nl
Justin A. MacDonald
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type
label
Justin A. MacDonald
@ast
Justin A. MacDonald
@en
Justin A. MacDonald
@es
Justin A. MacDonald
@nl
Justin A. MacDonald
@sl
prefLabel
Justin A. MacDonald
@ast
Justin A. MacDonald
@en
Justin A. MacDonald
@es
Justin A. MacDonald
@nl
Justin A. MacDonald
@sl
P106
P1153
55574230872
P21
P31
P496
0000-0002-9238-8473