about
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakThe BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cellsNET formation can occur independently of RIPK3 and MLKL signaling.The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavageCharacterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membraneIntracellular localization of the BCL-2 family member BOK and functional implicationsBok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal InjuryEssential versus accessory aspects of cell death: recommendations of the NCCD 2015.IVIG regulates the survival of human but not mouse neutrophils.Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.XIAP discriminates between type I and type II FAS-induced apoptosis.BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytesBID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints.The generation of neutrophils in the bone marrow is controlled by autophagyRole of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage.Bcl-w(edding) with mitochondria.Fas death receptor signalling: roles of Bid and XIAP.Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected].Conformational control of Bax localization and apoptotic activity by Pro168.TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent mannerConsequences of the combined loss of BOK and BAK or BOK and BAX.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasisLoss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils.Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction.TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.Novel insights into mechanisms of food allergy and allergic airway inflammation using experimental mouse models.BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma.Survival control of malignant lymphocytes by anti-apoptotic MCL-1.Impact of inhibitor of apoptosis proteins on immune modulation and inflammation.The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.Balance between IL-3 and type Iinterferons and their interrelationship with FasL dictates lifespan and effector functions of human basophils.Basophils exhibit antibacterial activity through extracellular trap formation.Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein.XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.Targeting disease by immunomodulation.Is BOK required for apoptosis induced by endoplasmic reticulum stress?
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Thomas Kaufmann
@ast
Thomas Kaufmann
@en
Thomas Kaufmann
@es
Thomas Kaufmann
@nl
type
label
Thomas Kaufmann
@ast
Thomas Kaufmann
@en
Thomas Kaufmann
@es
Thomas Kaufmann
@nl
prefLabel
Thomas Kaufmann
@ast
Thomas Kaufmann
@en
Thomas Kaufmann
@es
Thomas Kaufmann
@nl
P106
P1153
57203069380
P21
P2798
P31
P496
0000-0001-9906-874X