Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade - Wikidata - wikimedia - TriplyDB

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

http://www.wikidata.org/entity/Q42433996

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The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells Mast cell homeostasis and the JAK-STAT pathway Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms STAT5 in hematopoietic stem cell biology and transplantation The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5 Nilotinib in patients with systemic mastocytosis: analysis of the phase 2, open-label, single-arm nilotinib registration study Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis.Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder Oncogenic KIT mutations in different exons lead to specific changes in melanocyte phospho-proteome.FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation.Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives.NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia.Surveillance strategies for gastrointestinal stromal tumors.Indolent systemic mastocytosis limited to the bone: a case report and review of the literature.STAT signaling in the pathogenesis and treatment of myeloid malignancies.Oxidative metabolism in cancer: A STAT affair?STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis.Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy.Current treatment options in patients with mastocytosis: status in 2015 and future perspectives.Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia.Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts.Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization.The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses.Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis.AXL regulates mesothelioma proliferation and invasiveness.Targeted Treatment Options in Mastocytosis.Acetylation and sumoylation control STAT5 activation antagonistically.Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells

P2860

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P2860

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

http://www.wikidata.org/entity/Q42433996

description

2008 nî lūn-bûn

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Oncogenic Kit controls neoplas ...... 5/PI3-kinase signaling cascade

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Oncogenic Kit controls neoplas ...... 5/PI3-kinase signaling cascade

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type

label

Oncogenic Kit controls neoplas ...... 5/PI3-kinase signaling cascade

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Oncogenic Kit controls neoplas ...... 5/PI3-kinase signaling cascade

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prefLabel

Oncogenic Kit controls neoplas ...... 5/PI3-kinase signaling cascade

@en

Oncogenic Kit controls neoplas ...... 5/PI3-kinase signaling cascade

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Oncogenic Kit controls neoplas ...... 5/PI3-kinase signaling cascade

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Cédric Boudot

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Fabrice Gouilleux

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Jean Gondry

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Katrin Friedbichler

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Kaïss Lassoued

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Laurence Bénit

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Marc Kerenyi

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Noria Harir

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Peter Valent

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P2860

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures

Stat5 expression is critical for mast cell development and survival

Stat5a is essential for the proliferation and survival of murine mast cells

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus

Essential role for Gab2 in the allergic response

Critical role for Gab2 in transformation by BCR/ABL

Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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2463-2473

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6

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Richard Moriggl

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5276036

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