Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells.
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Unexploited Antineoplastic Effects of Commercially Available Anti-Diabetic DrugsIntegration of Mitochondrial Targeting for Molecular Cancer TherapeuticsApoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activitiesEltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survivalMetformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.Programmed cell death induced by (-)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditionsMetformin inhibits growth of human glioblastoma cells and enhances therapeutic responseMetformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells.Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibitionThe pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia.Co-activation of AMPK and mTORC1 as a new therapeutic option for acute myeloid leukemia.Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transportDichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells.Expanding the therapeutic spectrum of metformin: from diabetes to cancer.Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine.Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells.Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling.Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells.Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells.Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells.Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism.Metformin Enhanced in Vitro Radiosensitivity Associates with G2/M Cell Cycle Arrest and Elevated Adenosine-5'-monophosphate-activated Protein Kinase Levels in Glioblastoma.High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells.Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms.Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cellsEffect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance geneMetformin, an Anti-diabetic Drug to Target Leukemia
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P2860
Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Mitochondrial energetic and AK ...... ormin in human leukemic cells.
@en
Mitochondrial energetic and AK ...... ormin in human leukemic cells.
@nl
type
label
Mitochondrial energetic and AK ...... ormin in human leukemic cells.
@en
Mitochondrial energetic and AK ...... ormin in human leukemic cells.
@nl
prefLabel
Mitochondrial energetic and AK ...... ormin in human leukemic cells.
@en
Mitochondrial energetic and AK ...... ormin in human leukemic cells.
@nl
P2093
P2860
P50
P356
P1433
P1476
Mitochondrial energetic and AK ...... formin in human leukemic cells
@en
P2093
F Théodoro
G Danet-Desnoyers
P2860
P2888
P304
P356
10.1038/LEU.2013.107
P577
2013-04-09T00:00:00Z
P5875
P6179
1013907394