Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.
about
Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.Cell polarity defines three distinct domains in pancreatic β-cells.The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathiesWhole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes.Differential effects on β-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes.An age of enlightenment for cilia: The FASEB summer research conference on the "Biology of Cilia and Flagella"Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.Bardet-Biedl syndrome: Is it only cilia dysfunction?Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling.Local and regional control of calcium dynamics in the pancreatic islet.The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance.5'-AMP-activated protein kinase plays an essential role in geniposide-regulated glucose-stimulated insulin secretion in rat pancreatic INS-1 β cells.Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells.New Roles of the Primary Cilium in Autophagy.The role of primary cilia in obesity and diabetes.Collective Sensing of β-Cells Generates the Metabolic Code.Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function.The role of beta cell heterogeneity in islet function and insulin release.
P2860
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P2860
Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
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name
Ciliary dysfunction impairs be ...... of type 2 diabetes in rodents.
@en
Ciliary dysfunction impairs be ...... of type 2 diabetes in rodents.
@nl
type
label
Ciliary dysfunction impairs be ...... of type 2 diabetes in rodents.
@en
Ciliary dysfunction impairs be ...... of type 2 diabetes in rodents.
@nl
prefLabel
Ciliary dysfunction impairs be ...... of type 2 diabetes in rodents.
@en
Ciliary dysfunction impairs be ...... of type 2 diabetes in rodents.
@nl
P2093
P2860
P356
P1476
Ciliary dysfunction impairs be ...... of type 2 diabetes in rodents.
@en
P2093
Barbara Leibiger
Claes-Göran Östenson
Ingo B Leibiger
Jantje M Gerdes
Noah Moruzzi
Patrick Karlsson-Edlund
Philip L Beales
Sonia Christou-Savina
P2860
P2888
P356
10.1038/NCOMMS6308
P407
P577
2014-11-06T00:00:00Z