Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.
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A comprehensive glossary of autophagy-related molecules and processes (2nd edition)PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neuronsOxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's diseaseThe protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathwayBcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitroIdebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout miceGambogenic acid kills lung cancer cells through aberrant autophagyArabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence.Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's diseaseReversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndromeMitochondrial dynamics and Parkinson's disease: focus on parkin.Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO miceProtease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells.TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.P73 and age-related diseases: is there any link with Parkinson Disease?The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia.Mitophagy and Parkinson's disease: the PINK1-parkin link.Cytotoxicity of mutant huntingtin fragment in yeast can be modulated by the expression level of wild type huntingtin fragment.Quality control of mitochondrial proteostasis.Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway.The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway.Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases.The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation.Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.Regulation of autophagy by α1-antitrypsin: "a foe of a foe is a friend".Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2.Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.Identification of the Functional Autophagy-Regulatory Domain in HCLS1-Associated Protein X-1 That Resists Against Oxidative Stress.Melatonin protects against rotenone-induced cell injury via inhibition of Omi and Bax-mediated autophagy in Hela cells.Mitochondrial Dysfunction in Parkinson's Disease.HTRA2 variations in Taiwanese Parkinson's disease.The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes.Mitochondrial Regulation by PINK1-Parkin Signaling
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P2860
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Omi/HtrA2 is a positive regula ...... in neurodegenerative diseases.
@en
Omi/HtrA2 is a positive regula ...... in neurodegenerative diseases.
@nl
type
label
Omi/HtrA2 is a positive regula ...... in neurodegenerative diseases.
@en
Omi/HtrA2 is a positive regula ...... in neurodegenerative diseases.
@nl
prefLabel
Omi/HtrA2 is a positive regula ...... in neurodegenerative diseases.
@en
Omi/HtrA2 is a positive regula ...... in neurodegenerative diseases.
@nl
P2093
P50
P356
P1476
Omi/HtrA2 is a positive regula ...... in neurodegenerative diseases
@en
P2093
P2888
P304
P356
10.1038/CDD.2010.55
P577
2010-05-14T00:00:00Z
P5875
P6179
1013826228