The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine.
about
Molecular insights into the premature aging disease progeriaNuclear lamins and oxidative stress in cell proliferation and longevityRecent advances in understanding the role of lamins in health and diseaseStructural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donorsPotential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesRepression of the Antioxidant NRF2 Pathway in Premature AgingTemsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular PhenotypeA pathway linking oxidative stress and the Ran GTPase system in progeria.Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies.Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases.DNA damage and laminsMouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndromeThe role of DNA damage in laminopathy progeroid syndromes.Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.Generation and characterization of multipotent stem cells from established dermal culturesRapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamicsProgerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation.Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell?Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fatesAltered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment.Oxydative stress alters nuclear shape through lamins dysregulation: a route to senescence.Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.Nuclear lamin functions and disease.Lamin aggregation is an early sensor of porphyria-induced liver injuryProgeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxideProgeria Research Day at Brunel University.Nuclear damages and oxidative stress: new perspectives for laminopathies.How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale.Hutchinson-Gilford progeria syndrome through the lens of transcription.Mechanisms of vascular calcification in CKD-evidence for premature ageing?Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathiesExpression of progerin does not result in an increased mutation rate.The nuclear lamina in health and disease.Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome.Gating neural development and aging via nuclear pores.Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium.
P2860
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P2860
The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
The accumulation of un-repaira ...... atment with N-acetyl cysteine.
@en
The accumulation of un-repaira ...... atment with N-acetyl cysteine.
@nl
type
label
The accumulation of un-repaira ...... atment with N-acetyl cysteine.
@en
The accumulation of un-repaira ...... atment with N-acetyl cysteine.
@nl
prefLabel
The accumulation of un-repaira ...... atment with N-acetyl cysteine.
@en
The accumulation of un-repaira ...... atment with N-acetyl cysteine.
@nl
P2093
P2860
P356
P1476
The accumulation of un-repaira ...... atment with N-acetyl cysteine.
@en
P2093
Christopher J Hutchison
Giovanna Lattanzi
Joanne Muter
Pamela Ritchie
Shane A Richards
P2860
P304
P356
10.1093/HMG/DDR327
P577
2011-08-01T00:00:00Z