mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
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Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondJudicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesmTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTORThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance.Growing knowledge of the mTOR signaling network.Roles of F-box proteins in cancerDual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis.Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2)Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.Ubiquitination in disease pathogenesis and treatment.Signaling crosstalk between the mTOR complexes.mTORC2 is a tyrosine kinase.Hsp27 and F-box protein β-TrCP promote degradation of mRNA decay factor AUF1.mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy.The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling.Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis.Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr-/- mice with diet-induced insulin resistance.
P2860
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P2860
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
mTOR complex 2 regulates prope ...... ubiquitin ligase subunit Fbw8.
@en
mTOR complex 2 regulates prope ...... ubiquitin ligase subunit Fbw8.
@nl
type
label
mTOR complex 2 regulates prope ...... ubiquitin ligase subunit Fbw8.
@en
mTOR complex 2 regulates prope ...... ubiquitin ligase subunit Fbw8.
@nl
prefLabel
mTOR complex 2 regulates prope ...... ubiquitin ligase subunit Fbw8.
@en
mTOR complex 2 regulates prope ...... ubiquitin ligase subunit Fbw8.
@nl
P2093
P2860
P1433
P1476
mTOR complex 2 regulates prope ...... ubiquitin ligase subunit Fbw8.
@en
P2093
Chang-chih Wu
Michael A DeStefano
Monica Finlan
Nicole M Vega-Cotto
Sung Jin Kim
Won Jun Oh
P2860
P304
P356
10.1016/J.MOLCEL.2012.09.029
P577
2012-11-08T00:00:00Z