A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.
about
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.Molecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibitionHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesMolecular dynamics simulations of rhodopsin point mutants at the cytoplasmic side of helices 3 and 6.Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.New small molecule agonists to the thyrotropin receptor.Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH.TNFalpha mediates the skeletal effects of thyroid-stimulating hormoneCharacterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1.Molecular Insights into the Transmembrane Domain of the Thyrotropin ReceptorLigand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide.Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptorsThe thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders.Loss-of-function mutations in the thyrotropin receptor gene as a major determinant of hyperthyrotropinemia in a consanguineous community.The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists.Insight into the mechanism of dopamine D1-like receptor activation. Evidence for a molecular interplay between the third extracellular loop and the cytoplasmic tail.Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.Influence of the environment in the conformation of alpha-helices studied by protein database search and molecular dynamics simulations.Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation.Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond networkStructure and activation of the TSH receptor transmembrane domain.PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation.A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor.The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.Structural and functional role of helices I and II in rhodopsin. A novel interplay evidenced by mutations at Gly-51 and Gly-89 in the transmembrane domain.An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.Linking agonist binding to histamine H1 receptor activation.Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.
P2860
Q27638895-CCC8C0B6-D652-4847-98C1-C9CE4A190797Q28201665-A07F82E1-6244-4FBB-A653-D99B5FF82C99Q28476422-8B298813-362F-48C0-A0D7-FEAC809951E1Q28646207-43F5F825-F1F1-4F87-9698-79EFB1EA087DQ30368732-6275933D-B0ED-4D30-84B5-EE01DDC71EEBQ34179300-337CB27E-F8CC-4479-9ECA-57DA6C97CC6CQ34313795-F1A273C3-8F28-43B2-B49F-6EE9699616BCQ34918437-2B9BB597-1784-4137-97C8-A574F767B991Q35004622-7D4ECEAA-003F-4796-8C53-C5DBD0A0748EQ35036487-EE27E22C-7752-48DD-892C-06C095FA991CQ35214469-7A0B4118-704E-4966-984C-F661B7E7887AQ35834471-A4FA05C7-2D60-469F-A64D-CDE2E2F34929Q36234807-A7043796-9681-4FC9-AB8A-E09C7CDCBEDCQ36497002-96034BAA-68F6-4662-94EC-058BFE4B53FDQ36629258-E2790401-6BAA-4D3D-A1C3-16292E4A0AC5Q36630747-9B5C613D-959D-4F84-8D30-8050279744CBQ37197991-DC604350-2B5A-429A-9784-DBCF5DB00F8AQ37208197-4FBE6154-2D21-4F64-A445-CD19FF2EB7F6Q38289812-9ADE16F1-B4BE-4C8D-91C7-3FDC8AA61612Q38359032-5EA5AC88-2B6A-4D35-BF15-AE1BA301F878Q39614815-6634492C-2574-48CF-99F8-67D79ABF19EDQ40177137-917B97B7-7DD6-4FA0-8B4E-FA9DD560ECCCQ40208706-B08B47A4-ECD9-474F-A737-BA0ED19160F1Q40423659-0689B302-76F2-4611-A046-098CD5491B12Q41049560-877C937C-EC7C-4995-B8FF-3F60BBC48B41Q41455641-388A594E-E285-451B-A140-1183578E2BCEQ42131239-44F07F76-257D-4698-B7A4-4AE77F7EA817Q42425022-A29F2F40-FDB6-49D1-A139-A4E6E8D3F006Q42522311-B767481F-973F-40AD-A546-AC388B86142CQ42712396-A2EFF74B-F3A8-48F2-94E2-F462FCB9CBCFQ44238580-E932AA13-5171-49C5-8482-A0DE0AF5DFEAQ44378781-6629AD4E-11A0-4638-83BE-7C08F40464E8Q45275664-65ECB4F3-A67D-4384-914D-53D580E14B20Q46890983-67846B90-44FE-4A93-A84B-4C5FA818A3DFQ50207906-BE2ADB04-F718-4793-8407-652A0A694346
P2860
A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
A conserved Asn in transmembra ...... n of the thyrotropin receptor.
@en
A conserved Asn in transmembra ...... n of the thyrotropin receptor.
@nl
type
label
A conserved Asn in transmembra ...... n of the thyrotropin receptor.
@en
A conserved Asn in transmembra ...... n of the thyrotropin receptor.
@nl
prefLabel
A conserved Asn in transmembra ...... n of the thyrotropin receptor.
@en
A conserved Asn in transmembra ...... n of the thyrotropin receptor.
@nl
P2093
P2860
P356
P1476
A conserved Asn in transmembra ...... n of the thyrotropin receptor.
@en
P2093
Ballesteros JA
Costagliola S
Govaerts C
Van Sande J
P2860
P304
22991-22999
P356
10.1074/JBC.M102244200
P407
P577
2001-04-18T00:00:00Z