about
The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activationQuaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor.Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A ReceptorsLigand-specific regulation of the extracellular surface of a G-protein-coupled receptorCrystal structure of the µ-opioid receptor bound to a morphinan antagonistSerotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's diseaseOn the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in α-helix and β-barrel domains of membrane proteins.Relation between sequence and structure in membrane proteins.Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonismBenzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.Molecular basis of ligand dissociation in β-adrenergic receptorsInteractions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers.Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond.Selective binding of the TATA box-binding protein to the TATA box-containing promoter: analysis of structural and energetic factorsDesign and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.Chemical probes for the recognition of cannabinoid receptors in native systems.Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.The coexistence of a novel inactivating mutant thyrotropin receptor allele with two thyroid peroxidase mutations: a genotype-phenotype correlationA solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors.A molecular dissection of the glycoprotein hormone receptors.Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors.Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity.The specificity of binding of glycoprotein hormones to their receptors.The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.The G-protein coupled receptor family: actors with many faces.Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors.The role of hydrophobic amino acids in the structure and function of the rhodopsin family of G protein-coupled receptors.Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes.Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.
P50
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P50
description
hulumtues
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researcher
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ricercatore
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wetenschapper
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հետազոտող
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name
Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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type
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Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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prefLabel
Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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Leonardo Pardo
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P106
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P21
P214
P2456
P31
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0000-0003-1778-7420
P735
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viaf-305871775