Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.
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Positive and negative regulation of T-cell activation through kinases and phosphatasesEx vivo enzymatic treatment of aged CD4 T cells restores cognate T cell helper function and enhances antibody production in miceUnderstanding FRET as a research tool for cellular studiesAuxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicingCD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signalingCD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentInduction of polyclonal CD8+ T cell activation and effector function by Pertussis toxin.CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsA disease-associated polymorphism alters splicing of the human CD45 phosphatase gene by disrupting combinatorial repression by heterogeneous nuclear ribonucleoproteins (hnRNPs).A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.Contrasting alloreactive CD4+ and CD8+ T cells: there's more to it than MHC restriction.The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins.Different associations of CD45 isoforms with STAT3, PKC and ERK regulate IL-6-induced proliferation in myeloma.Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.Altered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus: the road from anergy to autoimmunity.T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective.New insights into viral structure and virus-cell interactions through proteomics.An extracatalytic function of CD45 in B cells is mediated by CD22.CD45: all is not yet crystal clear.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.Control of alternative splicing in immune responses: many regulators, many predictions, much still to learnExtracellular domain dependence of PTPalpha transforming activityDifferential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expressionAge-related changes in lck-Vav signaling pathways in mouse CD4 T cells.CD45-associated protein promotes the response of primary CD4 T cells to low-potency T-cell receptor (TCR) stimulation and facilitates CD45 association with CD3/TCR and lck.CD45RA and RO isoforms have distinct effects on cytokine- and B-cell-receptor-mediated signalling in human B cells.Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase alpha dimers.Identification of cells deficient in signaling-induced alternative splicing by use of somatic cell genetics.Nuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells.Reactive oxygen species and epidermal growth factor are antagonistic cues controlling SHP-2 dimerization.Combinations of CD45 isoforms are crucial for immune function and diseaseBinding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons.The analysis of CD45 isoforms expression on HBV-specific T cells after liver transplantation.Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes.Intracellular calcium signalling patterns reflect the differentiation status of human T cells.
P2860
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P2860
Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Differential association of CD ...... receptor signal transduction.
@en
Differential association of CD ...... receptor signal transduction.
@nl
type
label
Differential association of CD ...... receptor signal transduction.
@en
Differential association of CD ...... receptor signal transduction.
@nl
prefLabel
Differential association of CD ...... receptor signal transduction.
@en
Differential association of CD ...... receptor signal transduction.
@nl
P2093
P2860
P356
P1476
Differential association of CD ...... receptor signal transduction.
@en
P2093
Andrea Bodnar
Denis R Alexander
Janos Szollosi
John Gamble
Lindsey K Goff
Lou Alldridge
Nick Holmes
Peter Beverley
Saffron Dornan
P2860
P304
P356
10.1074/JBC.M108386200
P407
P50
P577
2001-11-02T00:00:00Z