PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes.
about
Cardiac regulation by phosphoinositide 3-kinases and PTENPhosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ currentCaV1.2 signaling complexes in the heartTherapeutic potential of PDE modulation in treating heart diseasePhosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterasesPhosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in miceRegulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat heartsPhosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cellsIntegrin-mediated protein kinase A activation at the leading edge of migrating cells.PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.Cardiac cyclic nucleotide phosphodiesterases: function, regulation, and therapeutic prospects.Advances in targeting cyclic nucleotide phosphodiesterasesDistinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium.Conserved expression and functions of PDE4 in rodent and human heart.Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Interventricular differences in β-adrenergic responses in the canine heart: role of phosphodiesterases.Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.Compartmentalization of beta-adrenergic signals in cardiomyocytes.Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heartPI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor.Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease.Specific PI3K isoform modulation in heart failure: lessons from transgenic mice.G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.Compartmentation of cAMP signalling in cardiomyocytes in health and disease.Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases.Cyclic nucleotide phosphodiesterases (PDEs): coincidence detectors acting to spatially and temporally integrate cyclic nucleotide and non-cyclic nucleotide signals.cAMP signaling in subcellular compartments.Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels.Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyteRegulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activationPhosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node MyocytesRole of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility.Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.Message delivered: how myocytes control cAMP signaling.Increased spontaneous activity and reduced inotropic response to catecholamines in ventricular myocytes from footshock-stressed rats.The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.
P2860
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P2860
PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
PI3Kgamma is required for PDE4 ...... cium ATPase in cardiomyocytes.
@en
PI3Kgamma is required for PDE4 ...... cium ATPase in cardiomyocytes.
@nl
type
label
PI3Kgamma is required for PDE4 ...... cium ATPase in cardiomyocytes.
@en
PI3Kgamma is required for PDE4 ...... cium ATPase in cardiomyocytes.
@nl
prefLabel
PI3Kgamma is required for PDE4 ...... cium ATPase in cardiomyocytes.
@en
PI3Kgamma is required for PDE4 ...... cium ATPase in cardiomyocytes.
@nl
P2093
P1433
P1476
PI3Kgamma is required for PDE4 ...... cium ATPase in cardiomyocytes.
@en
P2093
Benoit-Gilles Kerfant
Donald H Maurice
Dongling Zhao
Ilka Lorenzen-Schmidt
Lindsay S Wilson
Peter H Backx
S R Wayne Chen
Shitian Cai
P304
P356
10.1161/CIRCRESAHA.107.156422
P577
2007-07-05T00:00:00Z