Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.
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Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNTNMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: Candidate electrostatic interactions and microdomain formationTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsRNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoformsMutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptorsStructure and dynamics of DRD4 bound to an agonist and an antagonist using in silico approaches.Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations.Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization propertiesAction of molecular switches in GPCRs--theoretical and experimental studies.Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i)Molecular and pharmacological characterization of serotonin 5-HT2α and 5-HT7 receptors in the salivary glands of the blowfly Calliphora vicina.Human cannabinoid 1 GPCR C-terminal domain interacts with bilayer phospholipids to modulate the structure of its membrane environment.The cannabinoid type-1 receptor carboxyl-terminus, more than just a tail.Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site.Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors.Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.Identification of specific transmembrane residues and ligand-induced interface changes involved in homo-dimer formation of a yeast G protein-coupled receptor.Constitutive activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket.In silico Exploration of the Conformational Universe of GPCRs.7TM Domain Structure of Adhesion GPCRs.Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation.Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptor.Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs.Mechanisms of inverse agonist action at D2 dopamine receptors.Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints.Structural and functional role of helices I and II in rhodopsin. A novel interplay evidenced by mutations at Gly-51 and Gly-89 in the transmembrane domain.Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor.An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor.Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.Exploring GPCR-Ligand Interactions with the Fragment Molecular Orbital (FMO) Method.GPCRs: What Can We Learn from Molecular Dynamics Simulations?Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations.Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding.Modeling GPCR active state conformations: the β(2)-adrenergic receptor.
P2860
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P2860
Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Conserved helix 7 tyrosine act ...... nd double revertant mutations.
@en
Conserved helix 7 tyrosine act ...... nd double revertant mutations.
@nl
type
label
Conserved helix 7 tyrosine act ...... nd double revertant mutations.
@en
Conserved helix 7 tyrosine act ...... nd double revertant mutations.
@nl
prefLabel
Conserved helix 7 tyrosine act ...... nd double revertant mutations.
@en
Conserved helix 7 tyrosine act ...... nd double revertant mutations.
@nl
P2093
P2860
P356
P1476
Conserved helix 7 tyrosine act ...... and double revertant mutations
@en
P2093
Barbara J Ebersole
Cassandra Prioleau
Irache Visiers
Stuart C Sealfon
P2860
P304
36577-36584
P356
10.1074/JBC.M206223200
P407
P577
2002-07-26T00:00:00Z