Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated.
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Transient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseAlzheimer's disease--a panorama glimpseMapping the conformational dynamics and pathways of spontaneous steric zipper Peptide oligomerizationMolecular basis for amyloid- polymorphismAntiparallel -sheet architecture in Iowa-mutant -amyloid fibrilsMolecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain TissueMolecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic ResonanceDistinct α-synuclein strains differentially promote tau inclusions in neuronsMolecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation.Recent progress in understanding Alzheimer's β-amyloid structures.The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequenceAntiparallel triple-strand architecture for prefibrillar Aβ42 oligomersProgress towards structural understanding of infectious sheep PrP-amyloid.Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.Fiber diffraction data indicate a hollow core for the Alzheimer's aβ 3-fold symmetric fibril.Flexibility and Solvation of Amyloid-β Hydrophobic CoreFast Motions of Key Methyl Groups in Amyloid-β Fibrils.Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH.Intrinsic linear heterogeneity of amyloid β protein fibrils revealed by higher resolution mass-per-length determinations.Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine corePoint mutations in Aβ result in the formation of distinct polymorphic aggregates in the presence of lipid bilayers.Analysis of the Amyloidogenic Potential of Pufferfish (Takifugu rubripes) Islet Amyloid Polypeptide Highlights the Limitations of Thioflavin-T Assays and the Difficulties in Defining AmyloidogenicitySerial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brainImpact of sequence on the molecular assembly of short amyloid peptides.Physical and structural basis for polymorphism in amyloid fibrilsOrientation of aromatic residues in amyloid cores: structural insights into prion fiber diversityStructural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growthAmyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review.Amyloid polymorphism: structural basis and neurobiological relevance.Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue levelPoint mutations in Aβ induce polymorphic aggregates at liquid/solid interfaces.Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neuronsA Detailed Analysis of the Morphology of Fibrils of Selectively Mutated Amyloid β (1-40).Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and propertiesConformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect.Influence of temperature on formation of perfect tau fragment fibrils using PRIME20/DMD simulationsPrions and the potential transmissibility of protein misfolding diseases
P2860
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P2860
Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Abeta(1-40) forms five distinc ...... il stabilities are correlated.
@en
type
label
Abeta(1-40) forms five distinc ...... il stabilities are correlated.
@en
prefLabel
Abeta(1-40) forms five distinc ...... il stabilities are correlated.
@en
P2093
P2860
P1476
Abeta(1-40) forms five distinc ...... il stabilities are correlated.
@en
P2093
Angela D Williams
Ravindra Kodali
Ronald Wetzel
Saketh Chemuru
P2860
P304
P356
10.1016/J.JMB.2010.06.023
P407
P577
2010-06-18T00:00:00Z